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  1. Insights into the burden, needs and treatment of migraine from internet-based surveys in diverse real-world migraine populations are needed, especially at a time when novel preventive migraine medications are ...

    Authors: Julio Pascual, Tommaso Panni, Grazia Dell’Agnello, Saygin Gonderten, Diego Novick and Stefan Evers
    Citation: The Journal of Headache and Pain 2023 24:88
    Content type: Review Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2023 24:142

  2. The Notch gene, a highly evolutionarily conserved gene, was discovered approximately 110 years ago and has been found to play a crucial role in the development of multicellular organisms. Notch receptors and t...

    Authors: Yan Zhang, Tingting Wang, Sanlan Wu, Li Tang, Jia Wang, Jinghan Yang, Shanglong Yao and Yan Zhang
    Citation: The Journal of Headache and Pain 2023 24:87
    Content type: Review Published on:

  3. Mindfulness gained considerable attention for migraine management, but RCTs are lacking. We aimed to assess the efficacy of a six-sessions mindfulness-based treatment added to treatment as usual (TaU) in patie...

    Authors: Licia Grazzi, Domenico D’Amico, Erika Guastafierro, Greta Demichelis, Alessandra Erbetta, Davide Fedeli, Anna Nigri, Emilio Ciusani, Corso Barbara and Alberto Raggi
    Citation: The Journal of Headache and Pain 2023 24:86
    Content type: Research Published on:

  4. Tension-type headache (TTH) is the most prevalent primary headache disorder. Neck pain is commonly associated with primary headaches and the trigemino-cervical complex (TCC) refers to the convergence of trigem...

    Authors: Nico Sollmann, Paul Schandelmaier, Dominik Weidlich, Jonathan Stelter, Gabby B. Joseph, Corinna Börner, Severin Schramm, Meinrad Beer, Claus Zimmer, Mirjam N. Landgraf, Florian Heinen, Dimitrios C. Karampinos, Thomas Baum and Michaela V. Bonfert
    Citation: The Journal of Headache and Pain 2023 24:84
    Content type: Research Published on:

  5. Migraine is a very common headache disorder on the population level, characterized by symptomatic attacks (activity). For many people with migraine, the migraine symptoms intermittently or permanently cease du...

    Authors: Marco Piccininni, Ralph Brinks, Jessica L. Rohmann and Tobias Kurth
    Citation: The Journal of Headache and Pain 2023 24:83
    Content type: Research Published on:

  6. The close relationship between pain and mental health problems is well-known, and psychological intervention can provide an effective alternative to medication-based pain relief. However, previous studies on t...

    Authors: Chongjie Yao, Yuchen Zhang, Ping Lu, Bin Xiao, Pingping Sun, Jiming Tao, Yanbin Cheng, Lingjun Kong, Dongsheng Xu and Min Fang
    Citation: The Journal of Headache and Pain 2023 24:82
    Content type: Research Published on:

  7. Menstrual migraine is a subtype of migraine disease that is typically more disabling, longer-lasting, and more challenging to treat. The purpose of this network meta-analysis (NMA) is to compare the relative e...

    Authors: Han Zhang, Jian-Zhi Qi and Zhi-Hua Zhang
    Citation: The Journal of Headache and Pain 2023 24:81
    Content type: Review Published on:

  8. New daily persistent headache (NDPH) is a rare primary headache disorder characterized by daily and persistent sudden onset headaches. The pathogenesis of NDPH remains unclear, and there are few white matter i...

    Authors: Yanliang Mei, Wei Wang, Dong Qiu, Ziyu Yuan, Xiaoyan Bai, Hefei Tang, Peng Zhang, Xue Zhang, Yaqing Zhang, Xueying Yu, Binbin Sui and Yonggang Wang
    Citation: The Journal of Headache and Pain 2023 24:80
    Content type: Research Published on:

  9. The majority of epidemiological studies on migraine have been conducted in a specific country or region, and there is a lack of globally comparable data. We aim to report the latest information on global migra...

    Authors: Luying Fan, Yuhang Wu, Jiehua Wei, Fan Xia, Yufeng Cai, Senmao Zhang, Junxiang Miao, Yunzhe Zhou, Chu Liu, Wei Yan, Dan Liu, Lizhang Chen and Tingting Wang
    Citation: The Journal of Headache and Pain 2023 24:79
    Content type: Research Published on:

  10. Prior clinical studies suggest a shared mechanism between vestibular symptoms and migraine headache. However, the specific neuroanatomical substrate connecting vestibular symptoms with migraine remains to be l...

    Authors: Yun Zhang, Yixin Zhang, Yanyun Wang, Xiaoyan Zhang, Guangcheng Qin, Dunke Zhang, Lixue Chen and Jiying Zhou
    Citation: The Journal of Headache and Pain 2023 24:77
    Content type: Research Published on:

  11. Migraine is a common and complex neurological disease potentially caused by a polygenic interaction of multiple gene variants. Many genes associated with migraine are involved in pathways controlling the synap...

    Authors: Daniela Felício, Andreia Dias, Sandra Martins, Estefânia Carvalho, Alexandra M. Lopes, Nádia Pinto, Carolina Lemos, Mariana Santos and Miguel Alves-Ferreira
    Citation: The Journal of Headache and Pain 2023 24:78
    Content type: Brief Report Published on:

  12. Migraine is a disabling and chronic neurovascular headache disorder. Trigeminal vascular activation and release of calcitonin gene-related peptide (CGRP) play a pivotal role in the pathogenesis of migraine. Th...

    Authors: Linda Al-Hassany, Deirdre M. Boucherie, Hannah Creeney, Ruben W. A. van Drie, Fatemeh Farham, Silvia Favaretto, Cédric Gollion, Lou Grangeon, Hannah Lyons, Karol Marschollek, Dilara Onan, Umberto Pensato, Emily Stanyer, Marta Waliszewska-Prosół, Wietse Wiels, Hui Zhou Chen…
    Citation: The Journal of Headache and Pain 2023 24:76
    Content type: Review Published on:

  13. Real-world data are accumulating on the effectiveness, tolerability and safety of anti-calcitonin gene-related peptide pathway monoclonal antibodies for the preventive treatment of migraine. We performed a sys...

    Authors: Nicolas Vandenbussche, Karolina Pisarek and Koen Paemeleire
    Citation: The Journal of Headache and Pain 2023 24:75
    Content type: Review Published on:

  14. Authors: Nadja Bredo Rasmussen, Christina Deligianni, Casper Emil Christensen, William Kristian Karlsson, Haidar Muhsen Al-Khazali, Tom Van de Casteele, Charlotte Granhall, Faisal Mohammad Amin and Messoud Ashina
    Citation: The Journal of Headache and Pain 2023 24:74
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2023 24:60

  16. Advanced neuroimaging techniques have extensively contributed to elucidate the complex mechanisms underpinning the pathophysiology of migraine, a neurovascular disorder characterized by episodes of headache as...

    Authors: Antonio Russo, Marcello Silvestro, Alessandro Tessitore, Ilaria Orologio, Alessandro Pasquale De Rosa, Rosa De Micco, Gioacchino Tedeschi, Fabrizio Esposito and Mario Cirillo
    Citation: The Journal of Headache and Pain 2023 24:71
    Content type: Review Published on:

  17. Repeat mild traumatic brain injuries (RmTBI) result in substantial burden to the public health system given their association with chronic post-injury pathologies, such as chronic pain and post-traumatic heada...

    Authors: Jennaya Christensen, Naomi MacPherson, Crystal Li, Glenn R. Yamakawa and Richelle Mychasiuk
    Citation: The Journal of Headache and Pain 2023 24:72
    Content type: Research Published on:

  18. Erenumab has demonstrated effectiveness for prevention of migraine attacks, but the treatment is costly, and a considerable proportion of patients do not respond to it. The Registry for Migraine study (REFORM)...

    Authors: William Kristian Karlsson, Håkan Ashina, Christopher Kjær Cullum, Rune Häckert Christensen, Haidar Muhsen Al-Khazali, Faisal Mohammad Amin and Messoud Ashina
    Citation: The Journal of Headache and Pain 2023 24:70
    Content type: Research Published on:

  19. Migraine is a debilitating disorder, and while the introduction of monoclonal antibodies (mAbs) has led to efficacious and tolerable responses, a substantial number of patients are so-called “non-responders”. ...

    Authors: Linda Al-Hassany, Nazia Karsan, Christian Lampl, Peter J. Goadsby and Antoinette MaassenVanDenBrink
    Citation: The Journal of Headache and Pain 2023 24:69
    Content type: Correspondence Published on:

  20. The main objective of this clinical practice guideline is to provide a series of recommendations for healthcare and exercise professionals, such as neurologists, physical therapists, and exercise physiologists...

    Authors: Roy La Touche, José Fierro-Marrero, Irene Sánchez-Ruíz, Borja Rodríguez de Rivera-Romero, Carlos Donato Cabrera-López, Sergio Lerma-Lara, Néstor Requejo-Salinas, Francisco de Asís-Fernández, Ignacio Elizagaray-García, Josué Fernández-Carnero, Luís Matesanz-García, Joaquín Pardo-Montero, Alba Paris-Alemany and Álvaro Reina-Varona
    Citation: The Journal of Headache and Pain 2023 24:68
    Content type: Research Published on:

  21. Migraine is a disabling neurological disorder whose diagnosis is based on clinical criteria. A shortcoming of these criteria is that they do not fully capture the underlying neurobiological factors and sex-spe...

    Authors: F. C. van Welie, L. A. Kreft, J. M. A. Huisman and G. M. Terwindt
    Citation: The Journal of Headache and Pain 2023 24:64
    Content type: Review Published on:

  22. Authors: Rosaria Greco, Miriam Francavilla, Chiara Demartini, Anna Maria Zanaboni, Mikael H. Sodergren, Sara Facchetti, Barbara Pacchetti, Michela Palmisani, Valentina Franco and Cristina Tassorelli
    Citation: The Journal of Headache and Pain 2023 24:67
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2023 24:48

  23. Chronic migraine (CM) is a common neurological disorder with complex pathogenesis. Evidence suggests that pituitary adenylate cyclase-activating peptide (PACAP) induces migraine-like attacks and may be potenti...

    Authors: Lily Zhang, Yanjie Zhou, Liu Yang, Yue Wang and Zheman Xiao
    Citation: The Journal of Headache and Pain 2023 24:66
    Content type: Research Published on:

  24. Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden. Improving mitochondrial function has promise as an effective treatment strategy for migraine. Szeto-Schiller ...

    Authors: Zhengming Shan, Yajuan Wang, Tao Qiu, Yanjie Zhou, Yu Zhang, Luyu Hu, Lili Zhang, Jingjing Liang, Man Ding, Shanghua Fan and Zheman Xiao
    Citation: The Journal of Headache and Pain 2023 24:65
    Content type: Research Published on:

  25. Anti-CGRP monoclonal antibodies have shown notable effectiveness and tolerability in migraine patients; however, data on their use in elderly patients is still lacking, as clinical trials have implicit age res...

    Authors: Albert Muñoz-Vendrell, Sergio Campoy, Edoardo Caronna, Alicia Alpuente, Marta Torres-Ferrus, Candela Nieves Castellanos, Marina Olivier, Jaume Campdelacreu, Joan Prat, Javier Camiña Muñiz, Francisco José Molina Martínez, Ane Mínguez-Olaondo, Marta Ruibal Salgado, Sonia Santos Lasaosa, María Pilar Navarro Pérez, Noemí Morollón…
    Citation: The Journal of Headache and Pain 2023 24:63
    Content type: Research Published on:

  26. Cortical spreading depression (CSD), a transient neuronal and glial depolarization that propagates slowly across the cerebral cortex, is the putative electrophysiological event underlying migraine aura and a h...

    Authors: Chiho Kudo, Andrea M. Harriott, Michael A. Moskowitz, Christian Waeber and Cenk Ayata
    Citation: The Journal of Headache and Pain 2023 24:62
    Content type: Research Published on:

  27. Migraine is a highly disabling health burden with multiple symptoms; however, it remains undertreated because of an inadequate understanding of its neural mechanisms. Neuropeptide Y (NPY) has been demonstrated...

    Authors: Chunxiao Yang, Zihua Gong, Xiaochen Zhang, Shuai Miao, Bozhi Li, Wei Xie, Tao Wang, Xun Han, Liang Wang, Zhao Dong and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2023 24:61
    Content type: Research Published on:

  28. Pituitary adenylate cyclase-activating polypeptide (PACAP), structurally related to vasoactive intestinal peptide (VIP), is one of the important mediators in the pathogenesis of migraine and is known to dilate...

    Authors: Nadja Bredo Rasmussen, Christina Deligianni, Casper Emil Christensen, William Kristian Karlsson, Haidar Muhsen Al-Khazali, Tom Van de Casteele, Charlotte Granhall, Faisal Mohammad Amin and Messoud Ashina
    Citation: The Journal of Headache and Pain 2023 24:60
    Content type: Research Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2023 24:74

  29. Neuroimaging studies have made an important contribution to our understanding of headache pathophysiology. This systematic review aims to provide a comprehensive overview and critical appraisal of mechanisms o...

    Authors: R. Messina, R. H. Christensen, I. Cetta, M. Ashina and M. Filippi
    Citation: The Journal of Headache and Pain 2023 24:58
    Content type: Review Published on:

  30. Monoclonal antibodies targeting the CGRP pathway are effective and safe for prophylactic treatment of episodic (EM) and chronic migraine (CM). In case of treatment failure of a CGRP pathway targeting mAb, phys...

    Authors: Andreas Straube, Gregor Broessner, Charly Gaul, Xenia Hamann, Joachim Hipp, Torsten Kraya and Lars Neeb
    Citation: The Journal of Headache and Pain 2023 24:59
    Content type: Research Published on:

  31. Although headache disorders are common, the current diagnostic approach is unsatisfactory. Previously, we designed a guideline-based clinical decision support system (CDSS 1.0) for diagnosing headache disorder...

    Authors: Xun Han, Dongjun Wan, Shuhua Zhang, Ziming Yin, Siyang Huang, Fengbo Xie, Junhong Guo, Hongli Qu, Yuanrong Yao, Huifang Xu, Dongfang Li, Sufen Chen, Faming Wang, Hebo Wang, Chunfu Chen, Qiu He…
    Citation: The Journal of Headache and Pain 2023 24:57
    Content type: Research Published on:

  32. While there are several trials that support the efficacy of various drugs for migraine prophylaxis against placebo, there is limited evidence addressing the comparative safety and efficacy of these drugs. We c...

    Authors: Christian Lampl, Antoinette MaassenVanDenBrink, Christina I. Deligianni, Raquel Gil-Gouveia, Tanvir Jassal, Margarita Sanchez-del-Rio, Uwe Reuter, Derya Uluduz, Jan Versijpt, Dena Zeraatkar and Simona Sacco
    Citation: The Journal of Headache and Pain 2023 24:56
    Content type: Research Published on:

  33. Accumulating data emphasizes the importance of olfaction in migraine pathophysiology. However, there are only a few studies evaluating how the migraine brain processes olfactory stimulation, and virtually no s...

    Authors: Coralie Mignot, Vanda Faria, Thomas Hummel, Marie Frost, Christoph M. Michel, Gudrun Gossrau and Antje Haehner
    Citation: The Journal of Headache and Pain 2023 24:55
    Content type: Research Published on:

  34. The aberrance of gray matter morphology in migraineurs has been widely investigated. However, it remains largely unknown whether there are illness duration-related hierarchical changes in the gray matter struc...

    Authors: Tao Yin, Lei Lan, Zilei Tian, Zhengjie Li, Mailan Liu, Yujie Gao, Fanrong Liang and Fang Zeng
    Citation: The Journal of Headache and Pain 2023 24:53
    Content type: Research Published on:

  35. Migraine affects 1.1 billion people globally and is the second leading cause of disability worldwide. In clinical trials, treatment efficacy is evaluated by comparing the differential responses in the treatmen...

    Authors: Stewart J. Tepper, Jessica Cirillo, Edward Kim, Gil L’Italien, Julie M. Tweedie, Kunal Lodaya, Dushon Riley, Farah Pathan, Nicholas Antaki, Brian H. Nathanson and Peter McAllister
    Citation: The Journal of Headache and Pain 2023 24:54
    Content type: Research Published on:

  36. Although studies have identified a high prevalence of migraine among employees in the banking sector, the symptoms of migraine, related disability and occupational risk factors are not well understood.

    Authors: Du Wei, Tharani Loganathan and Li Ping Wong
    Citation: The Journal of Headache and Pain 2023 24:52
    Content type: Research Published on:

  37. This study compares the outcome of patients suffering from medically refractory classical trigeminal neuralgia (TN) after treatment with radiosurgery using two different shot sizes (5- and 6-mm).

    Authors: Cécile Ortholan, Philippe Colin, Benjamin Serrano, Thibault Bouet, Nicolas Garnier, Maud le Guyader, Regis Amblard, Rémy Villeneuve, Stéphane Chanalet, Haiel Alchaar, Eric Bozzolo, Michel Lanteri-Minet and Denys Fontaine
    Citation: The Journal of Headache and Pain 2023 24:51
    Content type: Research Published on:

  38. Dental treatment associated with unadaptable occlusal alteration can cause chronic primary myofascial orofacial pain. The serotonin (5-HT) pathway from the rostral ventromedial medulla (RVM) exerts descending ...

    Authors: Si-Yi Mo, Yang Xue, Yuan Li, Yao-Jun Zhang, Xiao-Xiang Xu, Kai-Yuan Fu, Barry J. Sessle, Qiu-Fei Xie and Ye Cao
    Citation: The Journal of Headache and Pain 2023 24:50
    Content type: Research Published on:

  39. Trace amines, such as tyramine, are endogenous amino acid metabolites that have been hypothesized to promote headache. However, the underlying cellular and molecular mechanisms remain unknown.

    Authors: Yuan Zhang, Hua Wang, Yufang Sun, Zitong Huang, Yu Tao, Yiru Wang, Xinghong Jiang and Jin Tao
    Citation: The Journal of Headache and Pain 2023 24:49
    Content type: Research Published on:

  40. Cannabidiol (CBD) is the main pharmacologically active phytocannabinoid. CBD exerts an analgesic effect in several pain models, does not have side effects and has low toxicity. The data about CBD mechanisms of...

    Authors: Rosaria Greco, Miriam Francavilla, Chiara Demartini, Anna Maria Zanaboni, Mikael H. Sodergren, Sara Facchetti, Barbara Pacchetti, Michela Palmisani, Valentina Franco and Cristina Tassorelli
    Citation: The Journal of Headache and Pain 2023 24:48
    Content type: Research Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2023 24:67

  41. Social cognition refers to all mental operations to decipher information needed in social interactions. Here we aimed to outline the socio-cognitive profile of Chronic Migraine with Medication Overuse (CM + MO...

    Authors: Sara Bottiroli, Alessia Rosi, Grazia Sances, Marta Allena, Roberto De Icco, Serena Lecce, Tomaso Vecchi, Cristina Tassorelli and Elena Cavallini
    Citation: The Journal of Headache and Pain 2023 24:47
    Content type: Research Published on:

  42. The pathogenesis of new daily persistent headache (NDPH) is not fully understood. We aim to map aberrant functional connectivity (FC) in patients with NDPH using resting-state functional magnetic resonance ima...

    Authors: Wei Wang, Ziyu Yuan, Xueyan Zhang, Xiaoyan Bai, Hefei Tang, Yanliang Mei, Dong Qiu, Yingkui Zhang, Peng Zhang, Xue Zhang, Yaqing Zhang, Xueying Yu, Binbin Sui and Yonggang Wang
    Citation: The Journal of Headache and Pain 2023 24:46
    Content type: Research Published on:

  43. New daily persistent headache (NDPH) is a rare but debilitating primary headache disorder that poses a significant burden on individuals and society. Despite its clinical importance, the underlying pathophysio...

    Authors: Dong Qiu, Wei Wang, Yanliang Mei, Hefei Tang, Ziyu Yuan, Peng Zhang, Yaqing Zhang, Xueying Yu, Chunqing Yang, Qun Wang and Yonggang Wang
    Citation: The Journal of Headache and Pain 2023 24:45
    Content type: Research Published on:

  44. Central sensitization has been widely accepted as an underlying pathophysiological mechanism of chronic migraine (CM), activation of cannabinoid type-1 receptor (CB1R) exerts antinociceptive effects by relievi...

    Authors: Xiaoxu Zeng, Jia Mai, Hongjian Xie, Ling Yang and Xiaojuan Liu
    Citation: The Journal of Headache and Pain 2023 24:44
    Content type: Research Published on:

  45. Neuroanatomical alterations have been associated with cognitive deficits in mild traumatic brain injury (MTBI). However, most studies have focused on the abnormal gray matter volume in widespread brain regions...

    Authors: Hui Xu, Cheng Xu, Pengpeng Gu, Yike Hu, Yunyu Guo and Guanghui Bai
    Citation: The Journal of Headache and Pain 2023 24:43
    Content type: Research Published on:

  46. Migraine is a severely debilitating disorder that affects millions of people worldwide. Studies have indicated that activation of protease-activated receptor-2 (PAR2) in the dura mater causes headache response...

    Authors: Bianca N. Mason, Shayne N. Hassler, Kathryn DeFea, Scott Boitano, Josef Vagner, Theodore J. Price and Greg Dussor
    Citation: The Journal of Headache and Pain 2023 24:42
    Content type: Research Published on:

  47. Migraine is one of the most prevalent and disabling medical diseases in the world. The periaqueductal gray matter and the red nucleus play an important role in its pathogenesis. Our aim was to evaluate the ech...

    Authors: Dolores Vilas, Sara Rubio, Mireia Gea, Jose Rios, Lourdes Ispierto, María Hernández-Pérez, Martí Paré, Mònica Millán and Laura Dorado
    Citation: The Journal of Headache and Pain 2023 24:41
    Content type: Research Published on:

  48. The Migraine in Poland study is the first large scale nationwide cross-sectional online survey of symptoms, approaches to management, treatment patterns, quality of life, and sociodemographic characteristics o...

    Authors: Marta Waliszewska-Prosół, Marcin Straburzyński, Ewa K. Czapińska-Ciepiela, Magdalena Nowaczewska, Anna Gryglas-Dworak and Sławomir Budrewicz
    Citation: The Journal of Headache and Pain 2023 24:40
    Content type: Research Published on:

  49. The aim of this paper is to critically re-appraise the published trials assessing amitriptyline for migraine prophylaxis.

    Authors: Christian Lampl, Jan Versijpt, Faisal Mohammad Amin, Christina I. Deligianni, Raquel Gil-Gouveia, Tanvir Jassal, Antoinette MaassenVanDenBrink, Raffaele Ornello, Jakob Paungarttner, Margarita Sanchez-del-Rio, Uwe Reuter, Derya Uluduz, Tessa de Vries, Dena Zeraatkar and Simona Sacco
    Citation: The Journal of Headache and Pain 2023 24:39
    Content type: Research Published on:

  50. Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids (endoCBs) 2-arachidonoylglycerol (2-AG) and anandamide...

    Authors: Adriana Della Pietra, Georgii Krivoshein, Konstantin Ivanov, Raisa Giniatullina, Henna-Kaisa Jyrkkänen, Ville Leinonen, Marko Lehtonen, Arn M. J. M. van den Maagdenberg, Juha Savinainen and Rashid Giniatullin
    Citation: The Journal of Headache and Pain 2023 24:38
    Content type: Research Published on:
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