Table 2 Trends of therapeutic drugs prescribed in outpatients with migraine between 2018 and 2022

Total therapeutic drugs

1882

2096

1699

2010

2237

9924

0.133

–

Analgesics

1228 (65.25)

1404 (66.98)

1218 (71.69)

1427 (71.00)

1693 (75.68)

6970 (70.23)

0.221

<  0.001

 NSAIDs

461 (24.50)

477 (22.76)

514 (30.25)

561 (27.91)

769 (34.38)

2782 (28.03)

0.028

<  0.001

  Ibuprofen

161 (8.55)

158 (7.54)

181 (10.65)

189 (9.40)

321 (14.35)

1010 (10.18)

0.086

<  0.001

  loxoprofen

67 (3.56)

64 (3.05)

86 (5.06)

69 (3.43)

107 (4.78)

393 (3.96)

0.221

<  0.001

  Celecoxib

45 (2.39)

63 (3.01)

70 (4.12)

87 (4.33)

92 (4.11)

357 (3.60)

0.028

<  0.001

 Caffeine-containing agents

372 (19.77)

422 (20.13)

379 (22.31)

469 (23.33)

556 (24.85)

2198 (22.15)

0.086

<  0.001

 Opioids

298 (15.83)

388 (18.51)

267 (15.72)

338 (16.82)

297 (13.28)

1588 (16.00)

0.807

0.004

  Codeine/Ibuprofen

192 (10.20)

236 (11.26)

174 (10.24)

217 (10.80)

200 (8.94)

1019 (10.27)

1.000

0.123

  Dihydrocodeine/acetaminophen

30 (1.59)

67 (3.20)

23 (1.35)

49 (2.44)

43 (1.92)

212 (2.14)

1.000

0.797

 Acetaminophen

38 (2.02)

46 (2.19)

25 (1.47)

29 (1.44)

46 (2.06)

184 (1.85)

1.000

0.516

 CPMs

59 (3.13)

71 (3.39)

33 (1.94)

30 (1.49)

25 (1.12)

218 (2.20)

0.086

<  0.001

Migraine-specific agents

585 (31.08)

604 (28.82)

424 (24.96)

526 (26.17)

482 (21.55)

2621 (26.41)

0.462

<  0.001

 Triptans

556 (29.54)

604 (28.82)

424 (24.96)

526 (26.17)

482 (21.55)

2592 (26.12)

0.462

<  0.001

  Rizatriptan

331 (17.59)

414 (19.75)

288 (16.95)

379 (18.86)

349 (15.60)

1761 (17.74)

1.000

0.045

  zolmitriptan

197 (10.47)

190 (9.06)

136 (8.00)

147 (7.31)

133 (5.95)

803 (8.09)

0.086

<  0.001

 Ergotamine

29 (1.54)

0 (0.00)

0 (0.00)

0 (0.00)

0 (0.00)

29 (0.29)

0.289

<  0.001

Antiemetics

69 (3.67)

88 (4.20)

57 (3.35)

57 (2.84)

62 (2.77)

333 (3.36)

0.613

0.011