Table 3 Association between triptan exposure and vascular events at 90 days (Cohort study, Cox model)

Exposure to triptans

Controls (non-exposed)

1

1

Exposure to triptans (Triptan group)

1.243 (1.043–1.483)

1.252 (1.050–1.494)

Exposure to triptans (time-varying)

Currently exposed at the time of event

8.691 (5.186–14.564)

-

-

8.745 (5.214–14.668)

Not currently exposed at the time of event

0.930 (0.760–1.137)

0.926 (0.757–1.133

Cumulative dose (triptans) since index date (DDDs)

Controls (non-exposed)

1

-

1

-

< 12

1.861 (1.431–2.420)

1.852 (1.424–2.410)

12

1.172 (0.876–1.566)

1.173 (0.877–1.569)

> 12

0.600 (0.383–0.940)

0.598 (0.382–0.937)

Charlson’s score (0)

1

1–2

0.949 (0.644–1.399)

-

-

-

3–4

1.152 (0.674–1.967)

> 5

1.337 (0.646–2.767)

Days of hospitalization (0)

1

-

≤ 4

0.861 (0.539–1.375)

-

> 5

0.852 (0.537–1.351)

Number of medical visits (0–2)

1

-

-

-

3–4

1.154 (0.667–1.996)

5–7

0.907 (0.537–1.531)

> 7

1.223 (0.759–1.971)