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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: Effects of PDE-3 inhibition in persistent post-traumatic headache: evidence of cAMP-dependent signaling

Fig. 3

a. Baseline-Corrected Median Headache Intensity Scores after Cilostazol and Placebo. Median headache intensity scores, adjusted for baseline, following the administration of cilostazol and placebo during the 12-hour observational window. The baseline headache intensity scores were subtracted before calculating the area under the curve to minimize the impact of within-participant variations in headache at baseline between the two experimental sessions. The red line represents median headache intensity scores after cilostazol, while the black line signifies median headache intensity scores after placebo. b. Baseline-Corrected Mean Arterial Blood Pressures after Cilostazol and Placebo. Mean arterial blood pressure values, adjusted for baseline, following the administration of cilostazol and placebo within the 1-hour in-hospital observation window. The mean arterial blood pressure after cilostazol is represented by the red line, while the mean arterial blood pressure after placebo is depicted by the black line. c. Baseline-Corrected Mean Heart Rates after Cilostazol and Placebo. Mean heart rate values, adjusted for baseline, following the administration of cilostazol and placebo within the 1-hour in-hospital observation window. The mean heart rate after cilostazol is represented by the red line, while the mean heart rate after placebo is depicted by the black line.

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