Table 1 Summary of biomarker levels of patients

Age in years

27 (25;41)

31.6 (26.5;41.7)

34.9 (22.4;42.7)

0.84

Female

n = 12 (63%)

n = 11 (69%)

n = 20 (87%)

0.21

CSF/Serum QAlb

5.3 (4.3;7.2)

4.85 (3.78;6)

4.5 (3.5;5.8)

0.583

t-Tau CSF pg/ml

42.96 (35.13;70.57)

39.54 (16.87;65.95)

51.17 (36.23;64.83)

0.42

t-Tau Serum pg/ml

0.43 (0.33; 0.54)^a

0.3 (0.13;0.63)^a

0.69 (0.39;1.07)^a

0.038

GFAP CSF pg/ml

5340.77 (2905.59;6486.36)

4976.22 (3334.72;7233.63)

5050.26 (4373.31;5856.72)

0.999

GFAP Serum pg/ml

67.23 (57.84;111.04)

62.25 (38.53;99.93)

73.28 (52.63;81.11)

0.569

UCHL1 CSF pg/ml

752.17 (501.63;1170.98)

674.22 (603.45;781.81)

748.98 (602.21;845.07)

0.662

UCHL1 Serum pg/ml

13.89 (10.84;17.47)

16.51 (12.61;21.86)

14.82 (11.16;19.67)

0.573

NfL CSF pg/ml

324.59 (215.55;404.65)

297.895 (241.82;467.27)

281.4 (181.19;393.29)

0.644

NfL Serum pg/ml

4.42 (2.98;5.73)

3.88 (2.15;6.19)

3.599 (2.83;6.13)

0.834

s-TREM CSF pg/ml

25,947.34 (21,658.7;31,157.51)

26,591.31 (20,972.84;30,399.76)^a

24,656.7 (16,693.72;30,423.62)

0.8

s-TREM Serum pg/ml

22,455.88 (17,568.14;32,755.89)

24,322.96 (15,644.24;29,010.35)^a

19,409.59 (14,881.68;26,438.02)

0.55

CX3CL1 CSF pg/ml

0.15 (0.12;0.18)

0.18 (0.15;0.21)^a

0.19 (0.16;0.24)

0.039

CX3CL1 Serum pg/ml

0.8 (0.72;0.92)

0.83 (0.65;1.07)^a

0.87 (0.75;1.23)

0.445