Fig. 1

Box plots of the temporospatial profile of t-Tau. The median and IQR of t-Tau protein concentration in pg/ml in serum and CSF are presented. There is a significant difference in t-Tau protein concentration in serum between the interictal collected sample and the ictal collected sample of migraine patients (*p < 0.05). ROC curve analysis between the ictal and interictal collected migraine samples provided an AUC of 0.729 [AUC = 0.729 (95% CI 0.558 to 0.861, p = 0.006)]