Fig. 1
Model structure depicted as clinical states and permitted paths with (A) best supportive care (BSC) and (B) eptinezumab. Key: Ovals are clinical states. Arrows represent a permitted movement to or from a clinical state. Dashed ovals are clinical states with entry allowed from any other clinical state. * 3-month treatment holiday for assessment of natural improvement (maximum of five, 12 months between). â—Š Clinical state where natural improvement is permitted after five treatment holiday cycles (see methods for details of how natural history was applied)