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Table 3 Percentage of CTR positive neurons which co-express CGRP alone, amylin alone or CGRP and amylin together in rat and human DRG

From: Calcitonin receptor, calcitonin gene-related peptide and amylin distribution in C1/2 dorsal root ganglia

Species

Sex

% CTR positive neurons

CGRP only

Amylin only

CGRP/Amylin

CTR alone

Rat

Combined (6)

14 ± 3.7

17 ± 4.7

35 ± 4.3✝

34 ± 3.2✝

Female (3)

9 ± 2.5

27 ± 2.1

31 ± 7.7

33 ± 4.9

Male (3)

18 ± 6.6

7 ± 3.9^

39 ± 4.2

36 ± 5.1

Human

Combined (4)

16 ± 4.6

12 ± 2.7

56 ± 4.5

16 ± 3.2

Female (2)

14 ± 7.4

16 ± 4.5

54 ± 10

16 ± 7.2

Male (2)

17 ± 8.3

9 ± 1.5

57 ± 4.0

17 ± 2.8

  1. Combined data are the mean ± s.e.m from six individual rats (three female and three male) or four human cases (2 female and 2 male), individual animal or case numbers are shown as (n)
  2. ^P < 0.05 by unpaired Students’ t-test comparing between females and males within each species for each condition
  3. ✝P < 0.05 by unpaired Students’ t-test comparing the “Combined” % CTR-positive neurons expressing CGRP only, amylin only, CGRP and amylin together, or no co-expression with peptide between rats and humans
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The Journal of Headache and Pain

ISSN: 1129-2377

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