Calcitonin receptor, calcitonin gene-related peptide and amylin distribution in C1/2 dorsal root ganglia

Table 1 Percentage of neurons (β tubulin III) that express CGRP, amylin, CGRP and amylin together, CTR, and CTR and CGRP together in mouse, rat, and human DRG.

Species	Sex		% β tubulin III positive neurons
Species	Sex		CGRP	Amylin	CGRP/amylin	CTR	CTR/CGRP
Mouse	Combined (6)	Total	32 ± 2.1*	38 ± 4.0	19 ± 1.4*	44 ± 3.9	27 ± 4.2
	Combined (6)	Only	13 ± 1.2	19 ± 3.0	19 ± 1.4*	17 ± 3.2	27 ± 4.2
	Female (3)	Total	33 ± 2.9	43 ± 5.1	20 ± 2.6	39 ± 4.1	26 ± 6.0
	Female (3)	Only	13 ± 0.4	23 ± 2.9	20 ± 2.6	14 ± 6.3	26 ± 6.0
	Male (3)	Total	31 ± 3.6	33 ± 5.3	18 ± 1.4	49 ± 6.3	29 ± 7.0
	Male (3)	Only	13 ± 2.6	15 ± 4.4	18 ± 1.4	20 ± 0.7	29 ± 7.0
Rat	Combined (6)	Total	34 ± 2.3*	39 ± 1.9	17 ± 1.8*	43 ± 2.5	23 ± 3.2
	Combined (6)	Only	17 ± 1.7	22 ± 1.9*	17 ± 1.8*	20 ± 1.2	23 ± 3.2
	Female (3)	Total	31 ± 2.4	38 ± 3.9	16 ± 3.2	42 ± 4.8	21 ± 6.4
	Female (3)	Only	15 ± 3.1	22 ± 3.5	16 ± 3.2	21 ± 1.8	21 ± 6.4
	Male (3)	Total	36 ± 3.7	39 ± 1.8	18 ± 2.3	44 ± 2.4	25 ± 2.3
	Male (3)	Only	18 ± 1.3	21 ± 2.3	18 ± 2.3	19 ± 1.8	25 ± 2.3
Human	Combined (4)	Total	58 ± 6.5	45 ± 11	36 ± 7.0	47 ± 4.7	32 ± 7.4
	Combined (4)	Only	22 ± 5.5	9 ± 4.5	36 ± 7.0	15 ± 2.8	32 ± 7.4
	Female (2)	Total	53 ± 14	54 ± 21	39 ± 13	41 ± 7.0	21 ± 9.2
	Female (2)	Only	14 ± 0.7	15 ± 7.1	39 ± 13	20 ± 2.2	21 ± 9.2
	Male (2)	Total	62 ± 2.5	36 ± 11	33 ± 10	54 ± 1.6	43 ± 1.6
	Male (2)	Only	29 ± 7.1	3 ± 1.9	33 ± 10	11 + 0.0	43 ± 1.6

The “total” number represents the total percentage of β tubulin III neurons which express CGRP, amylin, CGRP and amylin together, CTR, or CTR and CGRP together. CGRP “Only” describes the percentage of β tubulin III neurons which express CGRP but not amylin. Amylin “only” describes the percentage of β tubulin III neurons which express amylin but not CGRP. CTR “ only” describes the percentage of β tubulin III neurons which express CTR but not CGRP. Combined data are the mean ± s.e.m from six individual rats or mice (three female and three male) or four human cases (2 female and 2 male), individual animal or case numbers are shown as (n)
*P < 0.05 by one-way ANOVA with post-hoc Bonferroni’s test comparing the total or only “Combined” % β tubulin III positive neurons expressing CGRP, amylin, CGRP/amylin, CTR or CTR/CGRP for mice or rats to humans. Females and males within each species for each condition were compared by unpaired Students’ t-test; no significant differences were observed.

ISSN: 1129-2377