Fig. 3From: The glymphatic system in migraine and other headachesRelationship between glymphatic system impairment, sleep disturbance and headache. Poor sleep can determine an impairment in the glymphatic flow which, in turn, leads to the accumulation of neuroexcitatory and pro-inflammatory chemicals involved in the development of headache. Headache itself can, directly or indirectly (via a dysfunction of the glymphatic system) exacerbate sleep disturbancesBack to article page