Fig. 1

Representation of the glymphatic system and the glymphatic flow. The glymphatic system is made of a network of PVS around arteries and veins throwing metabolic waste products away from the central nervous system. PVS is limited by the endfeets of astrocytes and is filled with the CSF. CSF is produced in the choroid plexi in the lateral ventricles and then is vehicled into the subarachoid space. From the subarachoid space the CSF streams into the PVS around pial arteries. Here CSF enters the brain tissue and mixes with the ISF. CSF-ISF flows into the perivenous space and reach the dura mater sinuses, the meningeal lymphatics and the cervical lymphnodes. PVS: perivascular space; CSF: cerebrospinal fluid; ISF: interstitial fluid