Fig. 10

Mechanism of AMPK involvement in central sensitization of chronic migraine. The expression of AMPK decreases in the TNC region of the NTG-induced CM mouse model, and the increased expression of UHRF1 may block the abnormal activation of AMPK caused by an increase in the ADP/ATP ratio. Activation of AMPK can inhibit the synthesis of CGRP and inhibit the activation of the NF-kB pathway, leading to microglia M2-type polarization, thereby inhibiting the secretion of pro-inflammatory cytokines IL1-β, IL-6, and TNF-α and promoting the secretion of anti-inflammatory cytokines IL-4 and IL-10 to alleviate central sensitization