Table 1 Relevant studies of acute treatment headache response at 15 or 30 min
From: Commentary on 2022 guidelines on clinical trial design in cluster headache and further suggestions
Trial and Year | Placebo | Suma SC | Zolmi NS | O2 low | O2 high | Suma NS | Headache Response Timeline Analyzed |
|---|---|---|---|---|---|---|---|
Ekbom 1991 [21] | 25%, n = 39 | 74%, n = 39 |  |  |  |  | 15 min |
Ekbom 1993 [20] | 35%, n = 88 | 75%, n = 93 |  |  |  |  | 15 min |
Cittadini 2006 [24] | 23%, n = 61 |  | 42%, n = 65 |  |  |  | 30 min |
Rapoport 2007 [22] | 30%, n = 59 |  | 50%, n = 52 |  |  |  | 30 min |
Fogan 1985 [27] | 33%, n = 63 |  |  | 68%, n = 74 |  |  | 15 min |
Cohen 2009 [26] | 20%, n = 148 |  |  |  | 78%, n = 150 |  | 15 min |
Dirkx 2018 [9] |  |  |  | 14%, n = 14 | 33%, n = 15 |  | 15 min |
Van Viet 2003 [23] | 26%, n = 77 |  |  |  |  | 57%, n = 77 | 30 min |