Exposure | Ncase | Ntotal | Prevalence | Univariable analysis | Model I a | Model II b | Model III c | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | ||||
Overall | 357 | 3510 | 10.2% | Â | Â | Â | Â | Â | Â | Â | Â |
CLI | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0–3 points | 162 | 899 | 18.0% | Referent |  | Referent |  | Referent |  | Referent |  |
 4 points | 86 | 788 | 10.9% | 0.56 (0.42–0.74) | < 0.001 | 0.58 (0.44–0.77) | < 0.001 | 0.57 (0.43–0.76) | < 0.001 | 0.57 (0.43–0.75) | < 0.001 |
 5 points | 51 | 776 | 6.6% | 0.32 (0.23–0.45) | < 0.001 | 0.34 (0.24–0.47) | < 0.001 | 0.33 (0.24–0.47) | < 0.001 | 0.33 (0.24–0.46) | < 0.001 |
 6 points | 38 | 636 | 6.0% | 0.29 (0.20–0.42) | < 0.001 | 0.31 (0.21–0.45) | < 0.001 | 0.30 (0.21–0.44) | < 0.001 | 0.30 (0.21–0.44) | < 0.001 |
 7–8 points | 20 | 411 | 4.9% | 0.23 (0.14–0.38) | < 0.001 | 0.25 (0.16–0.41) | < 0.001 | 0.25 (0.15–0.41) | < 0.001 | 0.25 (0.15–0.41) | < 0.001 |
Smoking | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0 point | 24 | 153 | 15.7% | Referent |  | Referent |  | Referent |  | Referent |  |
 1 point | 333 | 3357 | 9.9% | 0.59 (0.38–0.93) | 0.022 | 0.73 (0.46–1.17) | 0.193 | 0.71 (0.44–1.15) | 0.163 | 0.69 (0.43–1.11) | 0.129 |
Physical activity | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0 point | 113 | 944 | 12.0% | Referent |  | Referent |  | Referent |  | Referent |  |
 1 point | 244 | 2566 | 9.5% | 0.77 (0.61–0.98) | 0.033 | 0.93 (0.72–1.20) | 0.570 | 0.94 (0.72–1.22) | 0.635 | 0.92 (0.71–1.19) | 0.525 |
Sleep | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0 point | 254 | 1789 | 14.2% | Referent |  | Referent |  | Referent |  | Referent |  |
 1 point | 103 | 1721 | 6.0% | 0.38 (0.30–0.49) | < 0.001 | 0.49 (0.38–0.64) | < 0.001 | 0.49 (0.38–0.64) | < 0.001 | 0.50 (0.38–0.65) | < 0.001 |
Stress | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0 point | 237 | 1832 | 12.9% | Referent |  | Referent |  | Referent |  | Referent |  |
 1 point | 120 | 1678 | 7.2% | 0.52 (0.41–0.65) | < 0.001 | 0.75 (0.59–0.96) | 0.023 | 0.74 (0.58–0.95) | 0.016 | 0.74 (0.58–0.95) | 0.019 |
Fatigue | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0 point | 253 | 1844 | 13.7% | Referent |  | Referent |  | Referent |  | Referent |  |
 1 point | 104 | 1666 | 6.2% | 0.42 (0.33–0.53) | < 0.001 | 0.62 (0.48–0.81) | < 0.001 | 0.63 (0.48–0.82) | 0.001 | 0.62 (0.48–0.81) | < 0.001 |
Diet | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0 point | 219 | 1692 | 12.9% | Referent |  | Referent |  | Referent |  | Referent |  |
 1 point | 138 | 1818 | 7.6% | 0.55 (0.44–0.69) | < 0.001 | 0.66 (0.52–0.83) | < 0.001 | 0.66 (0.52–0.83) | < 0.001 | 0.65 (0.52–0.83) | < 0.001 |
Body mass index | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0 point | 182 | 1793 | 10.2% | Referent |  | Referent |  | Referent |  | Referent |  |
 1 point | 175 | 1717 | 10.2% | 1.00 (0.81–1.25) | 0.967 | 1.00 (0.80–1.26) | 0.980 | 0.99 (0.79–1.24) | 0.925 | 0.98 (0.78–1.23) | 0.872 |
Alcohol | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0 point | 243 | 2122 | 11.5% | Referent |  | Referent |  | Referent |  | Referent |  |
 1 point | 114 | 1388 | 8.2% | 0.69 (0.55–0.87) | 0.002 | 0.80 (0.63–1.02) | 0.070 | 0.81 (0.63–1.03) | 0.082 | 0.81 (0.63–1.03) | 0.088 |
CLI (no smoking) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0–2 points | 161 | 886 | 18.2% | Referent |  | Referent |  | Referent |  | Referent |  |
 3 points | 85 | 783 | 10.9% | 0.55 (0.41–0.73) | < 0.001 | 0.57 (0.43–0.75) | < 0.001 | 0.56 (0.42–0.75) | < 0.001 | 0.56 (0.42–0.74) | < 0.001 |
 4 points | 53 | 790 | 6.7% | 0.32 (0.23–0.45) | < 0.001 | 0.34 (0.24–0.47) | < 0.001 | 0.34 (0.24–0.47) | < 0.001 | 0.34 (0.24–0.47) | < 0.001 |
 5 points | 38 | 633 | 6.0% | 0.29 (0.20–0.42) | < 0.001 | 0.31 (0.21–0.45) | < 0.001 | 0.30 (0.21–0.44) | < 0.001 | 0.30 (0.21–0.44) | < 0.001 |
 6–7 points | 20 | 418 | 4.8% | 0.23 (0.14–0.37) | < 0.001 | 0.25 (0.15–0.40) | < 0.001 | 0.24 (0.15–0.39) | < 0.001 | 0.24 (0.15–0.39) | < 0.001 |
CLI (no physical activity) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0–2 points | 129 | 692 | 18.6% | Referent |  | Referent |  | Referent |  | Referent |  |
 3 points | 98 | 759 | 12.9% | 0.65 (0.49–0.86) | 0.003 | 0.66 (0.50–0.88) | 0.005 | 0.66 (0.49–0.88) | 0.004 | 0.65 (0.49–0.87) | 0.004 |
 4 points | 64 | 845 | 7.6% | 0.36 (0.26–0.49) | < 0.001 | 0.37 (0.27–0.51) | < 0.001 | 0.37 (0.27–0.51) | < 0.001 | 0.37 (0.27–0.51) | < 0.001 |
 5 points | 42 | 723 | 5.8% | 0.27 (0.19–0.39) | < 0.001 | 0.28 (0.20–0.41) | < 0.001 | 0.28 (0.19–0.40) | < 0.001 | 0.28 (0.19–0.41) | < 0.001 |
 6–7 points | 24 | 491 | 4.9% | 0.22 (0.14–0.35) | < 0.001 | 0.24 (0.15–0.38) | < 0.001 | 0.24 (0.15–0.37) | < 0.001 | 0.24 (0.15–0.37) | < 0.001 |
CLI (no sleep) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0–2 points | 89 | 475 | 18.7% | Referent |  | Referent |  | Referent |  | Referent |  |
 3 points | 93 | 704 | 13.2% | 0.66 (0.48–0.91) | 0.010 | 0.69 (0.50–0.95) | 0.022 | 0.69 (0.50–0.95) | 0.021 | 0.68 (0.49–0.94) | 0.020 |
 4 points | 90 | 958 | 9.4% | 0.45 (0.33–0.62) | < 0.001 | 0.48 (0.35–0.66) | < 0.001 | 0.47 (0.34–0.65) | < 0.001 | 0.47 (0.34–0.65) | < 0.001 |
 5 points | 54 | 807 | 6.7% | 0.31 (0.22–0.45) | < 0.001 | 0.34 (0.23–0.49) | < 0.001 | 0.33 (0.23–0.48) | < 0.001 | 0.33 (0.23–0.48) | < 0.001 |
 6–7 points | 31 | 566 | 5.5% | 0.25 (0.16–0.39) | < 0.001 | 0.28 (0.18–0.44) | < 0.001 | 0.27 (0.18–0.43) | < 0.001 | 0.27 (0.17–0.42) | < 0.001 |
CLI (no stress) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0–2 points | 92 | 452 | 20.4% | Referent |  | Referent |  | Referent |  | Referent |  |
 3 points | 107 | 749 | 14.3% | 0.65 (0.48–0.89) | 0.006 | 0.67 (0.49–0.92) | 0.012 | 0.67 (0.49–0.91) | 0.010 | 0.67 (0.49–0.91) | 0.010 |
 4 points | 70 | 901 | 7.8% | 0.33 (0.24–0.46) | < 0.001 | 0.35 (0.25–0.49) | < 0.001 | 0.34 (0.24–0.48) | < 0.001 | 0.34 (0.24–0.48) | < 0.001 |
 5 points | 60 | 846 | 7.1% | 0.30 (0.21–0.42) | < 0.001 | 0.32 (0.23–0.46) | < 0.001 | 0.32 (0.22–0.45) | < 0.001 | 0.31 (0.22–0.45) | < 0.001 |
 6–7 points | 28 | 562 | 5.0% | 0.21 (0.13–0.32) | < 0.001 | 0.22 (0.14–0.35) | < 0.001 | 0.22 (0.14–0.35) | < 0.001 | 0.22 (0.14–0.34) | < 0.001 |
CLI (no fatigue) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0–2 points | 84 | 440 | 19.1% | Referent |  | Referent |  | Referent |  | Referent |  |
 3 points | 102 | 723 | 14.1% | 0.70 (0.51–0.96) | 0.025 | 0.73 (0.53–1.00) | 0.050 | 0.73 (0.53–1.00) | 0.050 | 0.73 (0.53–1.01) | 0.054 |
 4 points | 87 | 943 | 9.2% | 0.43 (0.31–0.60) | < 0.001 | 0.46 (0.33–0.64) | < 0.001 | 0.46 (0.33–0.63) | < 0.001 | 0.45 (0.32–0.63) | < 0.001 |
 5 points | 56 | 862 | 6.5% | 0.29 (0.21–0.42) | < 0.001 | 0.32 (0.22–0.46) | < 0.001 | 0.32 (0.22–0.46) | < 0.001 | 0.31 (0.22–0.46) | < 0.001 |
 6–7 points | 28 | 542 | 5.2% | 0.23 (0.15–0.36) | < 0.001 | 0.26 (0.16–0.40) | < 0.001 | 0.25 (0.16–0.40) | < 0.001 | 0.25 (0.16–0.39) | < 0.001 |
CLI (no diet) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0–2 points | 102 | 503 | 20.3% | Referent |  | Referent |  | Referent |  | Referent |  |
 3 points | 101 | 780 | 12.9% | 0.58 (0.43–0.79) | < 0.001 | 0.60 (0.45–0.82) | 0.001 | 0.61 (0.45–0.82) | 0.001 | 0.60 (0.44–0.82) | 0.001 |
 4 points | 71 | 849 | 8.4% | 0.36 (0.26–0.50) | < 0.001 | 0.38 (0.27–0.52) | < 0.001 | 0.38 (0.27–0.53) | < 0.001 | 0.38 (0.27–0.52) | < 0.001 |
 5 points | 48 | 772 | 6.2% | 0.26 (0.18–0.38) | < 0.001 | 0.28 (0.19–0.40) | < 0.001 | 0.28 (0.19–0.40) | < 0.001 | 0.28 (0.19–0.40) | < 0.001 |
 6–7 points | 35 | 606 | 5.8% | 0.24 (0.16–0.36) | < 0.001 | 0.26 (0.17–0.40) | < 0.001 | 0.26 (0.17–0.39) | < 0.001 | 0.26 (0.17–0.39) | < 0.001 |
CLI (no body mass index) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0–2 points | 116 | 566 | 20.5% | Referent |  | Referent |  | Referent |  | Referent |  |
 3 points | 91 | 674 | 13.5% | 0.61 (0.45–0.82) | 0.001 | 0.62 (0.46–0.85) | 0.002 | 0.62 (0.46–0.85) | 0.002 | 0.61 (0.45–0.83) | 0.002 |
 4 points | 74 | 845 | 8.8% | 0.37 (0.27–0.51) | < 0.001 | 0.39 (0.28–0.54) | < 0.001 | 0.39 (0.28–0.53) | < 0.001 | 0.39 (0.28–0.53) | < 0.001 |
 5 points | 46 | 760 | 6.1% | 0.25 (0.17–0.36) | < 0.001 | 0.27 (0.18–0.38) | < 0.001 | 0.26 (0.18–0.38) | < 0.001 | 0.26 (0.18–0.37) | < 0.001 |
 6–7 points | 30 | 665 | 4.5% | 0.18 (0.12–0.28) | < 0.001 | 0.20 (0.13–0.31) | < 0.001 | 0.20 (0.13–0.30) | < 0.001 | 0.20 (0.13–0.30) | < 0.001 |
CLI (no alcohol) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0–2 points | 103 | 503 | 20.5% | Referent |  | Referent |  | Referent |  | Referent |  |
 3 points | 87 | 655 | 13.3% | 0.59 (0.44–0.81) | 0.001 | 0.62 (0.45–0.84) | 0.002 | 0.61 (0.44–0.84) | 0.002 | 0.62 (0.45–0.84) | 0.003 |
 4 points | 90 | 901 | 10.0% | 0.43 (0.32–0.59) | < 0.001 | 0.45 (0.33–0.62) | < 0.001 | 0.45 (0.33–0.61) | < 0.001 | 0.44 (0.32–0.61) | < 0.001 |
 5 points | 37 | 741 | 5.0% | 0.20 (0.14–0.30) | < 0.001 | 0.22 (0.15–0.32) | < 0.001 | 0.21 (0.14–0.32) | < 0.001 | 0.21 (0.14–0.31) | < 0.001 |
 6–7 points | 40 | 710 | 5.6% | 0.23 (0.16–0.34) | < 0.001 | 0.25 (0.17–0.38) | < 0.001 | 0.25 (0.17–0.37) | < 0.001 | 0.25 (0.17–0.37) | < 0.001 |
CLI-weak components d | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0–1 points | 53 | 375 | 14.1% | Referent |  | Referent |  | Referent |  | Referent |  |
 2 points | 138 | 1214 | 11.4% | 0.78 (0.55–1.10) | 0.151 | 0.84 (0.60–1.18) | 0.320 | 0.84 (0.59–1.18) | 0.317 | 0.83 (0.59–1.17) | 0.287 |
 3–4 points | 166 | 1921 | 8.6% | 0.57 (0.41–0.80) | 0.001 | 0.65 (0.47–0.92) | 0.014 | 0.65 (0.46–0.92) | 0.014 | 0.63 (0.45–0.89) | 0.009 |