Fig. 2
From: Arterial hypertension in the chronic evolution of migraine: bystander or risk factor? An overview
Migraine modifiable and non/modifiable risk factors and biological mechanisms associated with transition to chronic migraine (CM). Common pathophysiological factors between migraine and hypertension are represented in the middle. Abbreviations: BBB blood brain barrier, CGRP calcitonin gene related peptide, CSD: cortical spreading depression, ED endothelial dysfunction, HT hypertension, MMPs metalloproteinases, PAG periaqueductal grey, RAAS renin–angiotensin–aldosterone system. Created with biorender.com