Table 2 Details of the statistical results of the fMRI analyses
Anatomical region | Cluster size (voxels), n | T value | MNI coordinates (x,y,z) |
|---|---|---|---|
A) Main Effect: Pooled visits, all participants (n = 40), threshold: p < 0.001 [uncorrected], T > 3.31, minimum, cluster extent 25 voxels, df = 39 | |||
L cerebellum exterior | 4501 | 7.21 | -32,-56,-32 |
R central operculum | 3139 | 7.17 | 50,2,3 |
L cerebellum exterior | 3156 | 6.79 | -25,-65,-49 |
R cerebellum exterior | 1628 | 6.15 | 36,-52,-29 |
L posterior insula | 329 | 5.33 | -36,-10,4 |
L anterior insula | 121 | 5.13 | -35,5,4 |
Cerebellar vermal lobules I-V | 417 | 5.04 | 0,-49,-15 |
R cerebellum exterior | 765 | 4.93 | 32,-56,-49 |
R posterior insula | 115 | 4.42 | 40,-14,-5 |
L brainstem/ spinal trigeminal nucleus | 127 | 4.41 | -3,-42,-49 |
R brainstem/ spinal trigeminal nucleus | 122 | 4.41 | 7,-39,-47 |
L cerebellum exterior | 111 | 4.38 | -13,-44,-22 |
R thalamus | 65 | 4.18 | 6,-28,-2 |
Cerebellar vermal lobules XIII-X | 146 | 4.15 | 0,-61,-35 |
R cerebellum exterior | 158 | 4.12 | 16,-57,-47 |
R posterior insula | 27 | 4.09 | 41,-1,-16 |
R cerebellum exterior | 76 | 3.94 | 21,-64,-16 |
R putamen | 86 | 3.92 | 24,0,-12 |
R anterior insula | 30 | 3.92 | 38,7,-16 |
L central operculum | 96 | 3.87 | -50,6,3 |
R putamen | 29 | 3.87 | 30,-21,1 |
Cerebellar vermal lobules I-V | 72 | 3.79 | -11,-59,-16 |
L posterior insula | 35 | 3.79 | -39,-15,-6 |
R pallidum | 27 | 3.63 | 20,3,1 |
B) Response And Group Variance (n = 40) contrast [ammonia–air puffs]visit1 > [ammonia–air puffs]visit2, Verum Response>Placebo Response, threshold p < 0.001 [uncorrected], T > 3.32, minimum cluster extent 20voxels, df = 37) | |||
R central operculum | 43 | 4.19 | 56,8,0 |
L putamen | 110 | 3.91 | -20,16,0 |
L parahippocampal gyrus | 20 | 3.78 | -4,-6,1 |
R putamen | 24 | 3.74 | 25,10,-4 |
L putamen | 37 | 3.69 | -26,6,-6 |