Fig. 3
From: Tryptophan metabolites and gut microbiota play an important role in pediatric migraine diagnosis
Exploration of diagnostic microbial biomarkers and the association between gut microbiota and tryptophan metabolism. A Linear discriminant analysis effect size (LEfSe) analysis for identifying diagnostic microbial biomarkers. B AUC validation method for random forest. The number of genera (n = 19) at the point with the highest AUC value was selected to construct the predictive diagnostic model. C Random forest for identifying diagnostic microbial biomarkers. The importance of genera decreases from the top to the bottom, and based on the evaluation results of the AUC method, the top 19 genera were selected to construct a diagnostic model for pediatric migraine. D Receiver operating characteristic curve (ROC) analysis for the diagnostic value of microbial biomarkers modeled by ridge regression, LEfSe and random forest. E Correlation heatmap among gut bacterial genera of migraine children. F Comparison of the relative abundances of gut bacterial genera regulating tryptophan metabolism was used with the Mann–Whitney test