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Fig. 2 | The Journal of Headache and Pain

Fig. 2

From: Microglia TREM1-mediated neuroinflammation contributes to central sensitization via the NF-κB pathway in a chronic migraine model

Fig. 2

Blocking TREM1 alleviates pain hypersensitivity in CM mice. LR12 effectively prevented the decrease in both basal and acute mechanical withdrawal thresholds of the hind paw (a, b) and periorbital area (c, d) and extended the heat withdrawal latency (e, f) (n= 10). Acute hypersensitivity reactions were detected 2 hours after each NTG treatment. Values are the mean±SEM; two-way ANOVA and Tukey's post hoc tests; ***p < 0.001 vs. the VEH group; ###p < 0.001 vs. the NTG group; &&&p < 0.001, the NTG-LR12 group vs. the VEH-LR12 group

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The Journal of Headache and Pain

ISSN: 1129-2377

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