- GRADE rating and interpretation
- High:
Definitely more beneficial than Placebo
- Moderate:
Probably more beneficial than Placebo;
Probably less beneficial than Placebo
- Low:
May be more beneficial than Placebo
- Abbreviations: MHDs Monthly Headache Days, MMDs Monthly Migraine Days, MSQ-RR Migraine-Specific QoL-Restrictive Role, MSQ-PR Migraine-Specific QoL-Preventative Role, MSQ-EF Migraine-Specific QoL-Emotional Function, HIT-6 Headache Impact Test-6, ≥ 50% MHDs 50% or more response in MHDs reported in four trials (n= 3,039) [34, 41, 45, 46], ≥ 50% MMDs 50% or more response in MMDs reported in seven trials (n = 4,695) [32, 38,39,40, 43,44,45,46,47,48,49,50]
- adowngraded due to risk of bias
- bdowngraded due to imprecision