Association between impaired dynamic cerebral autoregulation and BBB disruption in reversible cerebral vasoconstriction syndrome

Table 3 BBB disruption and cerebral dysautoregulation in RCVS

parameter	frequency band	side	BBB disruption	No BBB disruption	HC	ANOVA p
Gain (%/%)	VLF	L	1.6 ± 0.6	1.5 ± 0.7	1.1 ± 0.4	0.004^*a,b
	VLF	R	1.6 ± 0.6	1.5 ± 0.8	1.1 ± 0.4	0.011^*a,b
	LF	L	1.9 ± 1.7	1.4 ± 0.6	1.3 ± 0.5	0.170^a
	LF	R	1.6 ± 0.8	1.4 ± 0.6	1.3 ± 0.5	0.221^a
Phase shift (°)	VLF	L	37.5 ± 18.1	65.3 ± 25.5	58 ± 19.3	< 0.001^*b
	VLF	R	37.7 ± 17.9	59.2 ± 28.1	58 ± 19.3	0.003^*b
	LF	L	18.2 ± 31.5	40.4 ± 29.6	37.5 ± 26.2	0.023^*b
	LF	R	19.7 ± 21.8	30.9 ± 18.5	37.5 ± 26.2	0.024^*b
Mx	N/A	L	0.46 ± 0.14	0.34 ± 0.22	0.31 ± 0.17	0.008^*b
Mx	N/A	R	0.48 ± 0.15	0.34 ± 0.18	0.31 ± 0.17	0.002^*b

Data presented as mean ± standard deviation. ^* p < 0.05. ^a calculated with Kruskal-Wallis tests. ^b Assessed by Cohen’s f showed medium to large effect size
BBB Blood-brain barrier, HC Healthy control, L Left, LF Low frequency, Mx Mean flow correlation index, N/A Not applicable, R Right, RCVS Reversible cerebral vasoconstriction syndrome, VLF Very-low frequency

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