Association between impaired dynamic cerebral autoregulation and BBB disruption in reversible cerebral vasoconstriction syndrome

Table 2 Dynamic cerebral autoregulation in HC and RCVS

parameter	frequency band	side	RCVS	HC	p
Gain (%/%)	VLF	L	1.6 ± 0.7	1.1 ± 0.4	0.001^*a,b
	VLF	R	1.5 ± 0.7	1.1 ± 0.4	0.003^*a,b
	LF	L	1.6 ± 1.2	1.3 ± 0.5	0.061^a,
	LF	R	1.5 ± 0.7	1.3 ± 0.5	0.120^a,
Phase shift (°)	VLF	L	53.7 ± 26.4	58.0 ± 19.3	0.378
	VLF	R	50.2 ± 26.4	58.0 ± 19.3	0.115
	LF	L	30.8 ± 32.0	37.5 ± 26.2	0.287
	LF	R	26.2 ± 20.5	37.5 ± 26.2	0.025^*c
Mx	N/A	L	0.39 ± 0.20	0.31 ± 0.17	0.040^*c
Mx	N/A	R	0.40 ± 0.18	0.31 ± 0.17	0.017^*b

Data presented as mean ± standard deviation. ^* p < 0.05. ^a calculated with Mann-Whitney U tests. ^b assessed by Cohen’s d showed medium to large effect. ^c assessed by Cohen’s d showed small to medium effect size
HC Healthy controls, L Left, LF Low frequency, Mx Mean flow correlation index, N/A Not applicable, R Right, RCVS Reversible cerebral vasoconstriction syndrome, VLF Very-low frequency

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