Fig. 3

Uncoupled integration of nociceptive information within trigemino-coerulean network in sensitized (IS4) conditions. Individual example (A) and cumulative results (B) of the activity evoked in TCC by application of IS on the meninges (at t = 0s) of naive (red, n = 15) and sensitized (orange, n = 12) animals. C Mean number of spikes of the C response of TCC evoked by 50 successives electrical stimulations of the meninges in naive (n = 15) and sensitized (n = 12) animals. Individual example (D) and cumulative results (E) of the activity evoked in LC by application of IS on the meninges (at t = 0s) of naive (dark blue, n = 22) and sensitized (light blue, n = 14) animals. F Late component within LC evoked by 50 successives electrical stimulations of the meninges in naive (n = 16) and sensitized (n = 11) animals. Horizontal line in boxplots represents median, bottom and top edges 25th and 75th percentiles respectively, and dots represent individual values. * P < 0.05, ** P < 0.01,  Mann–Whitney U test