Fig. 2

Alterations of trigemino-coerulean spontaneous oscillatory in conditions of dural nociceptor sensitization. A Representative examples of spectrograms from LC and TCC LFP recordings (top) and quantification of their delta power (bottom) shown above LC spontaneous activity, presenting slow oscillations. B to E Z-score of spikes phase preferences (mean ± SEM) calculated to obtain a pure time representation of probability of neuronal discharge, allowing to average across animals. Spikes phase preference (mean ± SEM) of TCC (red) and LC (blue) for intermediate (B, n = 12) and slow (C, n = 6) oscillations in naive rats. Spikes phase preference (mean ± SEM) of TCC (yellow) and LC (blue) for intermediate (D) and slow (E) oscillations in sensitized rats. F Precession of TCC preferred phase (slow oscillations) on LC preferred phase in naive (n = 6) versus sensitized animals after IS4 (n = 9)