Table 4 Responder rates in the entire study sample, chronic migraine patients and high-frequency episodic migraine patients at different time intervals
Entire study sample (n = 1055) (%) | Chronic migraine (n = 806) (%) | Episodic migraine (n = 249) (%) | FDR-adjusted P value | |
|---|---|---|---|---|
Weeks 8–12 | ||||
30%R PP (n = 958) | 64.1 | 59.3 | 79.8 | < 0.001 |
30%R ITT BCF (n = 1055) | 62.6 | 57.9 | 77.5 | < 0.001 |
30%R ITT LOCF (n = 1055) | 62.6 | 57.9 | 77.5 | < 0.001 |
50%R PP (n = 958) | 51.0 | 47.1 | 63.6 | < 0.001 |
50%R ITT BCF (n = 1055) | 49.8 | 46.0 | 61.8 | < 0.001 |
50%R ITT LOCF (n = 1055) | 49.8 | 46.0 | 61.8 | < 0.001 |
75%R PP (n = 958) | 24.8 | 22.3 | 32.6 | 0.001 |
75%R ITT BCF (n = 1055) | 24.2 | 21.8 | 31.7 | 0.001 |
75%R ITT LOCF (n = 1055) | 24.2 | 21.8 | 31.7 | 0.001 |
Weeks 20–24 | ||||
30%R PP (n = 810) | 71.6 | 68.8 | 80.4 | 0.001 |
30%R ITT BCF (n = 1055) | 60.9 | 57.8 | 70.7 | < 0.001 |
30%R ITT LOCF (n = 1055) | 65.4 | 61.0 | 79.5 | < 0.001 |
50%R PP (n = 810) | 48.7 | 54.6 | 66.2 | 0.003 |
50%R ITT BCF (n = 1055) | 48.8 | 45.9 | 58.2 | 0.001 |
50%R ITT LOCF (n = 1055) | 52.4 | 48.4 | 65.5 | < 0.001 |
75%R PP (n = 810) | 26.8 | 25.4 | 31.1 | 0.104 |
75%R ITT BCF (n = 1055) | 22.7 | 21.3 | 27.3 | 0.056 |
75%R ITT LOCF (n = 1055) | 24.6 | 22.5 | 31.7 | 0.003 |
Weeks 44–48 | ||||
30%R PP (n = 753) | 77.3 | 75.9 | 81.4 | 0.200 |
30%R ITT BCF (n = 1055) | 59.7 | 56.2 | 71.1 | < 0.001 |
30%R ITT LOCF (n = 1055) | 63.7 | 60.5 | 79.1 | < 0.001 |
50%R PP (n = 753) | 33.7 | 60.5 | 69.3 | 0.079 |
50%R ITT BCF (n = 1055) | 48.3 | 44.5 | 60.6 | < 0.001 |
50%R ITT LOCF (n = 1055) | 51.5 | 46.7 | 67.1 | < 0.001 |
75%R PP (n = 753) | 31.9 | 32.0 | 31.4 | 0.898 |
75%R ITT BCF (n = 1055) | 24.6 | 23.0 | 30.1 | 0.033 |
75%R ITT LOCF (n = 1055) | 26.3 | 23.8 | 34.1 | 0.001 |