Fig. 9

Progesterone modulation of capsaicin-induced vascular responses in rat basilar artery. A Depicts the contraction responses of male and female rats, expressed as a percentage of 60 mM K⁺. B Dilation responses following a pre-contraction with 100 nM U46619 are shown. Further, the differential capsaicin-induced responses in male (C) and female rats (D), following pre-treatment with 10 µM progesterone. C A significant increase in capsaicin-induced dilation is observed in male rats pre-treated with progesterone, while no significant difference was noted in female rats (D). Data are represented as mean ± SEM. A Two-way ANOVA with Sidak's post hoc test was used for statistical analysis