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Table 3 Base-case cost-effectiveness results comparing each medication separately

From: Competing treatments for migraine: a headache for decision-makers

 

Costs (£)

QALYs

Incremental costs (£)

Incremental QALYs

ICER: cost per QALY gained (£)

Deterministic results—discounted

 Placebo

£1,729

1.3531

-

-

-

 Topiramate

£1,624

1.3995

-£104

0.0464

Dominated

 Placebo

£1,729

1.3531

-

-

-

 BTA

£3,654

1.4294

£1,925

0.0763

£25,238

 Placebo

£1,729

1.3531

-

-

-

 Fremanezumab (monthly)

£10,155

1.4307

£8,427

0.0776

£108,604

 Placebo

£1,729

1.3531

-

-

-

 Fremanezumab (quarterly)

£10,193

1.4224

£8,465

0.0693

£122,126

 Placebo

£1,729

1.3531

-

-

-

 Eptinezumab 100

£10,216

1.4239

£8,487

0.0708

£119,796

 Placebo

£1,729

1.3531

-

-

-

 Galcanezumab

£10,640

1.4229

£8,912

0.0698

£127,649

 Placebo

£1,729

1.3531

-

-

-

 Eptinezumab 300

£27,401

1.4403

£25,672

0.0873

£294,151

Probabilistic results—discounted

 Placebo

£1,728

1.3460

-

-

-

 Topiramate

£1,624

1.4045

-£104

0.0584

Dominated

 Placebo

£1,728

1.3460

-

-

-

 BTA

£3,654

1.4270

£1,926

0.0810

£23,775

 Placebo

£1,728

1.3460

-

-

-

 Fremanezumab (monthly)

£10,161

1.4350

£8,433

0.0890

£94,748

 Placebo

£1,728

1.3460

-

-

-

 Fremanezumab (quarterly)

£10,196

1.4273

£8,467

0.0812

£104,251

 Placebo

£1,728

1.3460

-

-

-

 Eptinezumab 100

£10,221

1.4199

£8,492

0.0739

£114,894

 Placebo

£1,728

1.3460

-

-

-

 Galcanezumab

£10,646

1.4161

£8,917

0.0701

£127,279

 Placebo

£1,728

1.3460

-

-

-

 Eptinezumab 300

£27,411

1.4365

£25,683

0.0904

£284,030