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Table 2 Risks of MOH in relation to current use of tobacco

From: Sex differences in the clinical manifestations related to dependence behaviors in medication-overuse headache

 

Total

Sex-by-smoking interaction

Men

Women

OR (95% CI)

p value

OR (95% CI)

p value

OR (95% CI)

p value

OR (95% CI)

p value

Tobacco use

1.79 (1.25–2.56)

0.002

1.35 (0.89–2.06)

0.157

3.60 (1.73–7.50)

0.001

1.34 (0.88–2.04)

0.171

Male sex

1.06 (0.79–1.41)

0.712

0.91 (0.67–1.25)

0.563

    

Age (years)

1.00 (0.99–1.01)

0.528

1.00 (0.99–1.01)

0.602

1.00 (0.98–1.02)

0.968

1.00 (0.99–1.01)

0.622

Monthly headache days

1.00 (0.98–1.02)

0.873

1.00 (0.98–1.02)

0.977

0.97 (0.94–1.02)

0.207

1.01 (0.99–1.03)

0.494

CM duration (years)

1.03 (1.01–1.05)

< 0.001

1.03 (1.01–1.05)

< 0.001

1.13 (1.06–1.19)

< 0.001

1.02 (1.00–1.03)

0.033

Average headache intensity

1.24 (1.16–1.32)

< 0.001

1.24 (1.16–1.32)

< 0.001

1.17 (1.01–1.36)

0.038

1.26 (1.18–1.35)

< 0.001

HADS-A

0.98 (0.94–1.01)

0.154

0.98 (0.94–1.01)

0.152

0.94 (0.76–1.02)

0.129

0.99 (0.95–1.03)

0.498

HADS-D

1.03 (1.00–1.07)

0.091

1.03 (1.00–1.07)

0.090

1.05 (0.97–1.15)

0.232

1.03 (0.99–1.07)

0.198

PSQI

1.03 (1.00–1.06)

0.087

1.03 (1.00–1.06)

0.070

1.03 (0.96–1.11)

0.461

1.03 (0.99–1.06)

0.120

Sex-by-smoking interaction

  

2.63 (1.16–5.98)

0.021

    
  1. Abbreviations: CM Chronic migraine, HADS Hospital Anxiety and Depression Scale (A = anxiety subscale, D = depression subscale), MOH medication-overuse headache, PSQI Pittsburgh Sleep Quality Index