Fig. 9
From: BMP7 alleviates trigeminal neuralgia by reducing oligodendrocyte apoptosis and demyelination
AAV-BMP7 alleviated OL apoptosis in VC. A TUNEL (in red) and APC immunofluorescence (in pink) in the VC of each group at day 21 after the AAV injection. White arrows indicate TUNEL-positive APC staining and DAPI (in blue) labels nucleated cells; scale bar = 50 μm. B Quantification of cells with TUNEL-positive APC staining from (A); n = 3 per group. C, D Western blotting and the corresponding quantification for Bax and Bcl-2 in the VC of each group at day 21 after the AAV injection; n = 3 per group. Compared with the CCI + AAV-GFP group, ##p < 0.01. Compared with the Sham group, **p < 0.01, ****p < 0.0001. AAV = adeno-associated virus; OL = oligodendrocyte; VC = trigeminal spinal subnucleus caudalis; TUNEL = terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling; CCI = chronic constriction injury