Fig. 8
From: BMP7 alleviates trigeminal neuralgia by reducing oligodendrocyte apoptosis and demyelination
AAV-BMP7 alleviated demyelination and the loss of OLs after CCI. A, B TEM images show the myelin profiles in the VC of the CCI + AAV-GFP and CCI + AAV-BMP7 groups at day 21 after the AAV injection; scale bar = 20 μm. C G-ratios of myelin with different diameters which were calculated from (A, B); n = 3 per group.*p < 0.05 compared with the CCI + AAV-GFP group. D Immunofluorescence staining for APC in the VC of CCI + AAV-GFP and CCI + AAV-BMP7 groups at day 21 after the AAV injection; scale bar = 200 μm. E Mean fluorescence intensity of APC was calculated from (D); n = 3 per group.*p < 0.05 compared with the CCI + AAV-GFP IPS group. AAV = adeno-associated virus; OL = oligodendrocyte; CCI = chronic constriction injury; VC = trigeminal spinal subnucleus caudalis