Fig. 7

AAV-BMP7 relieved mechanical allodynia and demyelination after CCI. A MWT of rats in each group at the indicated time points after CCI; n = 6 per group. Compared with the CCI + AAV-GFP group, *p < 0.05. B–D mRNA and protein levels of BMP7 in the VC of each group at day 21 after the AAV injection; n = 3 per group. E–I mRNA and protein levels of OL markers (CNPase and MBP) in the VC of each group at day 21 after the AAV injection; n = 3 per group. mRNA levels in (B), (E), and (F) are presented as a fold change from the Sham group mRNA level. Protein bands depicted in (C) and (G) have the corresponding optical densities labeled in kiloDaltons (kD). Quantifications of these bands are shown in (D), (H), and (I), normalized by the GAPDH loading control. Compared with the CCI + AAV-GFP group, ^#p < 0.05, ^##p < 0.01, ^###p < 0.001. Compared with the Sham group, *p < 0.05, **p < 0.01, ***p < 0.001. AAV = adeno-associated virus; MWT = mechanical withdrawal threshold; CCI = chronic constriction injury