Fig. 5
From: BMP7 alleviates trigeminal neuralgia by reducing oligodendrocyte apoptosis and demyelination
ShRNA-BMP7 caused demyelination and the loss of OLs. A, B TEM images revealed the myelin profiles in the VC of shRNA-GFP and shRNA-BMP7 groups at day 21 after AAV injection; scale bar = 20 μm. C G-ratios of myelin with different diameters which were calculated from (A) and (B); n = 3 per group. **p < 0.01 compared with the shRNA-GFP group. D Immunofluorescence staining for APC in the VC of the shRNA-GFP and shRNA-BMP7 groups at day 21 after AAV injection; scale bar = 200 μm. E Mean fluorescence intensity of APC was calculated from (D); n = 3 per group. **p < 0.01 compared with the shRNA-GFP IPS group, #p < 0.05 compared with the shRNA-BMP7 CON group. shRNA = short hairpin RNA; IPS = ipsilateral; CON = contralateral; VC = trigeminal spinal subnucleus caudalis