Patient or population: migraine Intervention: prophylaxis with topiramate Comparison: placebo | |||||
---|---|---|---|---|---|
Outcomes | № of participants (studies) Follow-up | Certainty of the evidence (GRADE) | Relative effect (95% CI) | Anticipated absolute effects | |
Risk with placebo | Risk difference with topiramate | ||||
50% or more reduction in monthly migraine days | 1,959 (6 RCTs) | High | RR 1.61 (1.29 to 2.01) | 275 per 1,000 | 168 more per 1,000 (80 more to 278 more) |
Monthly migraine days | 2,361 (8 RCTs) | High | - | N/A | MD 0.99 migraine days fewer (1.41 fewer to 0.58 fewer) |
Adverse events leading to discontinuation | 1000 (8 RCTs) | High | RD 0.08 (0.02 to 0.14) | 0 per 1,000 | 80 more per 1,000 (20 more to 140 more) |