Fig. 3From: The potent analgesia of intrathecal 2R, 6R-HNK via TRPA1 inhibition in LF-PENS-induced chronic primary pain modelMultiple intrathecal HNK inhibits LF-PENS-induced depression and cognitive deficits, but not anxiety. a-d Multiple intrathecal 2R, 6R-HNK administration eliminated LF-PENS-induced changes in sucrose preference test (a), tail suspension test (b), forced swimming test (c), new object recognition test (d) at 3-w after stimuli. e Both dosages of 2R, 6R-HNK had no effect on anxiety-like behavior at 2-w after LF-PENS (n = 12 or 14 mice/group), *p < 0.05, **p < 0.01, ***p < 0.001 between groupsBack to article page