Fig. 3From: Impact of headache frequency and preventive medication failure on quality of life, functioning, and costs among individuals with migraine across several European countries: need for effective preventive treatmentModerate to severe depression and anxiety symptomology (PHQ-9 and GAD-7). Results were adjusted for age, sex, country, insurance type, body mass index category, smoking history, alcohol intake, exercise, and CCI. *P < 0.05, †P < 0.01, ‡P < 0.001 vs ≥ 2 preventive treatment failures group. aCriterion for “moderate to severe depression” was PHQ-9 score ≥ 10. bCriterion for “moderate to severe anxiety” was GAD-7 score ≥ 10. CCI, Charlson Comorbidity Index; GAD-7, Generalized Anxiety Disorder-7; PHQ-9, Patient Health Questionnaire-9Back to article page