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Table 2 Ten identified gene has not been reported to be associated with migraine in previous studies

From: Identifying causal genes for migraine by integrating the proteome and transcriptome

Region

Gene name

Type

Migraine TWAS

FOCUS

Model

R2

effect_size

P value

PIP

TWAS-Z

1p13.2

NGF-AS1

protein

Artery_Aorta

0.081728

-0.181164

2.86E-10

0.998

-6.09

1p36.21

FHAD1

protein

Anterior_cingulate_cortex_BA24

0.09331

-0.3653

3.39E-08

0.974

-5.04

   

Caudate_basal_ganglia

0.08647

-0.153907

1.93E-07

0.971

-5.01

   

Nucleus_accumbens_basal_ganglia_accumbens_basal_ganglia

0.098172

-0.114123

1.66E-07

0.984

-5.12

   

Putamen_basal_ganglia_basal_ganglia

0.055866

-0.20457

3.31E-07

0.941

-4.84

2q37.1

HJURP

protein

Caudate_basal_ganglia

0.070146

0.587219

2.72E-07

0.992

5.3

   

Nucleus_accumbens_basal_ganglia_accumbens_basal_ganglia

0.066215

0.554813

3.42E-08

1

5.92

5q13.3

POC5

protein

Amygdala

0.047456

0.164059

2.52E-07

-

1.01

   

Anterior_cingulate_cortex_BA24

0.042806

0.090769

2.65E-07

0.484

3.05

   

Cerebellar_Hemispher

0.282793

0.0786

1.56E-10

1

6.55

   

Cerebellum

0.263836

0.089549

1.72E-07

-

3.22

   

Cortex

0.156424

0.123317

2.23E-10

-

1.06

   

Frontal_Cortex_BA9

0.05286

0.130486

3.14E-08

-

0.935

   

Hippocampus

0.024359

0.282175

1.17E-08

-

-

   

Hypothalamus

0.035169

0.119661

4.11E-08

-

-

   

Nucleus_accumbens_basal_ganglia_accumbens_basal_ganglia

0.062625

0.125138

2.18E-08

-

0.255

   

Spinal_cord_cervical_c-1

0.048626

0.158599

1.17E-08

-

-

5q13.3

AC010245.2

lncRNA

Anterior_cingulate_cortex_BA24

0.05817

-0.337346

3.98E-10

-

-4.87

   

Caudate_basal_ganglia

0.028894

-0.52382

4.68E-11

0.999

-5.69

   

Frontal_Cortex_BA9

0.02653

-0.170674

3.66E-09

-

-

   

Hypothalamus

0.121593

-0.225619

6.60E-09

-

-

   

Putamen_basal_ganglia_basal_ganglia

0.022971

-0.323605

7.93E-10

-

-

   

Artery_Coronary

0.028216

-0.429415

1.21E-06

-

-

7p14.1

LINC01449

lncRNA

Artery_Aorta

0.120487

-0.13169

7.01E-15

-

-

   

Artery_Coronary

0.025357

-0.665014

3.76E-21

1

-9.05

   

Artery_Tibial

0.025121

-0.600408

2.15E-15

-

-

10q23.33

PLCE1-AS1

protein

Artery_Tibial

0.052699

-0.125025

1.75E-07

0.9

-4.86

10q23.33

TBC1D12

protein

Spinal_cord_cervical_c-1

0.065751

0.26911

3.45E-08

-

-

12p13.32

CCND2

protein

Artery_Tibial

0.037212

0.160604

7.97E-10

1

6.45

19q13.2

B9D2

protein

Anterior_cingulate_cortex_BA24

0.089763

-0.189229

4.54E-09

0.971

-5.05

   

Caudate_basal_ganglia

0.034965

-0.182969

8.13E-08

-

-

   

Cerebellum

0.035837

-0.218353

3.20E-08

0.971

-5.39

   

Cortex

0.026928

-0.402582

9.32E-11

1

-6.24

   

Frontal_Cortex_BA9

0.025896

-0.391737

8.97E-11

1

-6.24

   

Hippocampus

0.046359

-0.194721

6.01E-08

-

-

   

Hypothalamus

0.099981

-0.277185

3.47E-10

1

-5.84

   

Putamen_basal_ganglia_basal_ganglia

0.045991

-0.189611

2.24E-08

-

-

   

Artery_Tibial

0.025688

-0.322809

1.02E-10

1

-6.14