From: Identifying causal genes for migraine by integrating the proteome and transcriptome
Region | Gene name | Type | Migraine TWAS | FOCUS | ||||
---|---|---|---|---|---|---|---|---|
Model | R2 | effect_size | P value | PIP | TWAS-Z | |||
1p13.2 | NGF-AS1 | protein | Artery_Aorta | 0.081728 | -0.181164 | 2.86E-10 | 0.998 | -6.09 |
1p36.21 | FHAD1 | protein | Anterior_cingulate_cortex_BA24 | 0.09331 | -0.3653 | 3.39E-08 | 0.974 | -5.04 |
 |  |  | Caudate_basal_ganglia | 0.08647 | -0.153907 | 1.93E-07 | 0.971 | -5.01 |
 |  |  | Nucleus_accumbens_basal_ganglia_accumbens_basal_ganglia | 0.098172 | -0.114123 | 1.66E-07 | 0.984 | -5.12 |
 |  |  | Putamen_basal_ganglia_basal_ganglia | 0.055866 | -0.20457 | 3.31E-07 | 0.941 | -4.84 |
2q37.1 | HJURP | protein | Caudate_basal_ganglia | 0.070146 | 0.587219 | 2.72E-07 | 0.992 | 5.3 |
 |  |  | Nucleus_accumbens_basal_ganglia_accumbens_basal_ganglia | 0.066215 | 0.554813 | 3.42E-08 | 1 | 5.92 |
5q13.3 | POC5 | protein | Amygdala | 0.047456 | 0.164059 | 2.52E-07 | - | 1.01 |
 |  |  | Anterior_cingulate_cortex_BA24 | 0.042806 | 0.090769 | 2.65E-07 | 0.484 | 3.05 |
 |  |  | Cerebellar_Hemispher | 0.282793 | 0.0786 | 1.56E-10 | 1 | 6.55 |
 |  |  | Cerebellum | 0.263836 | 0.089549 | 1.72E-07 | - | 3.22 |
 |  |  | Cortex | 0.156424 | 0.123317 | 2.23E-10 | - | 1.06 |
 |  |  | Frontal_Cortex_BA9 | 0.05286 | 0.130486 | 3.14E-08 | - | 0.935 |
 |  |  | Hippocampus | 0.024359 | 0.282175 | 1.17E-08 | - | - |
 |  |  | Hypothalamus | 0.035169 | 0.119661 | 4.11E-08 | - | - |
 |  |  | Nucleus_accumbens_basal_ganglia_accumbens_basal_ganglia | 0.062625 | 0.125138 | 2.18E-08 | - | 0.255 |
 |  |  | Spinal_cord_cervical_c-1 | 0.048626 | 0.158599 | 1.17E-08 | - | - |
5q13.3 | AC010245.2 | lncRNA | Anterior_cingulate_cortex_BA24 | 0.05817 | -0.337346 | 3.98E-10 | - | -4.87 |
 |  |  | Caudate_basal_ganglia | 0.028894 | -0.52382 | 4.68E-11 | 0.999 | -5.69 |
 |  |  | Frontal_Cortex_BA9 | 0.02653 | -0.170674 | 3.66E-09 | - | - |
 |  |  | Hypothalamus | 0.121593 | -0.225619 | 6.60E-09 | - | - |
 |  |  | Putamen_basal_ganglia_basal_ganglia | 0.022971 | -0.323605 | 7.93E-10 | - | - |
 |  |  | Artery_Coronary | 0.028216 | -0.429415 | 1.21E-06 | - | - |
7p14.1 | LINC01449 | lncRNA | Artery_Aorta | 0.120487 | -0.13169 | 7.01E-15 | - | - |
 |  |  | Artery_Coronary | 0.025357 | -0.665014 | 3.76E-21 | 1 | -9.05 |
 |  |  | Artery_Tibial | 0.025121 | -0.600408 | 2.15E-15 | - | - |
10q23.33 | PLCE1-AS1 | protein | Artery_Tibial | 0.052699 | -0.125025 | 1.75E-07 | 0.9 | -4.86 |
10q23.33 | TBC1D12 | protein | Spinal_cord_cervical_c-1 | 0.065751 | 0.26911 | 3.45E-08 | - | - |
12p13.32 | CCND2 | protein | Artery_Tibial | 0.037212 | 0.160604 | 7.97E-10 | 1 | 6.45 |
19q13.2 | B9D2 | protein | Anterior_cingulate_cortex_BA24 | 0.089763 | -0.189229 | 4.54E-09 | 0.971 | -5.05 |
 |  |  | Caudate_basal_ganglia | 0.034965 | -0.182969 | 8.13E-08 | - | - |
 |  |  | Cerebellum | 0.035837 | -0.218353 | 3.20E-08 | 0.971 | -5.39 |
 |  |  | Cortex | 0.026928 | -0.402582 | 9.32E-11 | 1 | -6.24 |
 |  |  | Frontal_Cortex_BA9 | 0.025896 | -0.391737 | 8.97E-11 | 1 | -6.24 |
 |  |  | Hippocampus | 0.046359 | -0.194721 | 6.01E-08 | - | - |
 |  |  | Hypothalamus | 0.099981 | -0.277185 | 3.47E-10 | 1 | -5.84 |
 |  |  | Putamen_basal_ganglia_basal_ganglia | 0.045991 | -0.189611 | 2.24E-08 | - | - |
 |  |  | Artery_Tibial | 0.025688 | -0.322809 | 1.02E-10 | 1 | -6.14 |