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Table 1 Candidate genes in proteomes associated with migraine

From: Identifying causal genes for migraine by integrating the proteome and transcriptome

Gene

Chr

PWAS

TWAS significant

ROSMAP

Banner

Plasma

Z-score

p-valuea

Z-score

p-valueb

Z-score

p-valuec

XCL2

1

-

-

-

-

4.2627

2.02E-05

-

EPHA10

1

-

-

-

-

-4.1497

3.33E-05

-

ICA1L

2

-4.59488

4.33E-06

-4.5015

6.75E-06

-

-

Suggestive

TREX1

3

-4.6832

2.82E-06

-4.5604

5.11E-06

-

-

Suggestive

CISD2

4

4.2477

2.16E-05

4.1343

3.56E-05

-

-

-

UFL1

6

11.3956

4.4E-30

-

-

-

-

Suggestive

HNRNPK

9

-

-

4.5444

5.51E-06

-

-

-

PAPPA

9

-

-

-

-

4.9603

7.04E-07

-

PACSIN3

11

-

-

-4.7089

2.49E-06

-

-

-

MRVI1

11

-

-

-

-

-7.94798

1.90E-15

-

STAT6

12

-11.499

1.33E-30

-10.3081

6.48E-25

-

-

Suggestive

SUGP1

19

-4.1653

3.11E-05

-

-

-

-

-

B3GNT8

19

-

-

-

-

4.74602

2.07E-06

Suggestive

  1. PWAS proteome-wide association study
  2. aProteome-wide significance level in the ROSMAP dataset was set at p < 4.363E-5 (adjusted by Bonferroni multiple testing correction method)
  3. bProteome-wide significance level in the Banner dataset was set at p < 4.41E-5 (adjusted by Bonferroni multiple testing correction method)
  4. cProteome-wide significance level in the Plasma dataset was set at p < 3.71E-5 (adjusted by Bonferroni multiple testing correction method)
  5. The genes in bold are the ones that are significant in both the proteome-wide and transcriptome-wide levels
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The Journal of Headache and Pain

ISSN: 1129-2377

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