Fig. 2

Estimated systolic and diastolic blood pressure trajectories from mixed-effect models among patients who were (A) non-hypertensive or (B) hypertensive at baseline. Weighted model including fixed effect of treatment group, the natural spline function of time in years, an interaction between treatment group and time, baseline blood pressure, age, gender, race, BMI, smoking status, history of obstructive sleep apnea, chronic kidney disease, hyperlipidemia, diabetes, and random intercept of patient. Abbreviations: CGRP, calcitonin gene-related peptide