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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: Optogenetic cortical spreading depolarization induces headache-related behaviour and neuroinflammatory responses some prolonged in familial hemiplegic migraine type 1 mice

Fig. 3

Optogenetic CSDs cause a short-lasting increase in oculotemporal (OT) (head grooming) strokes in both WT and FHM1 mutant mice. A In both WT and FHM1 mutant mice, the number (#) of strokes was elevated 30 min after three optogenetically-induced CSDs (‘3x CSD’) and had normalized at 5 h after CSD. B The number of strokes did not change with sham stimulation. C-E Strokes from A at 30 min showed no difference in the occurrence of left (C), right (D), or bilateral (E) strokes between WT and FHM1 mutant mice. OT-L/OT-T: number of left OT strokes/total; OT-R/OT-T: number of right OT strokes/total; OT-B/OT-T: number of bilateral OT strokes/total. ** p < 0.01

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The Journal of Headache and Pain

ISSN: 1129-2377

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