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Table 3 Traditional preventive treatment patterns in OVERCOME (EU) migraine cohort and in survey respondents eligible for migraine preventive medication (excluding calcitonin gene-related peptide-monoclonal antibody users)

From: Preventive treatment patterns and treatment satisfaction in migraine: results of the OVERCOME (EU) study

OVERCOME (EU) migraine cohort

0–3 HD/m

(n = 13,759)

4–7 HD/m

(n = 4203)

8–14 HD/m

(n = 1730)

 ≥ 15 HD/m

(n = 1064)

Total

(N = 20,756)

Currentlyb using preventives,c n (%)

 1 preventive

943 (6.9)

358 (8.5)

171 (9.9)

129 (12.1)

1601 (7.7)

 2 preventives

514 (3.7)

188 (4.5)

92 (5.3)

68 (6.4)

862 (4.2)

  ≥ 3 preventives

1475 (10.7)

463 (11.0)

186 (10.8)

123 (11.6)

2247 (10.8)

Currentb preventive medication category,c n (%) – not mutually exclusive

 Antiseizured

1793 (13.0)

604 (14.4)

235 (13.6)

171 (16.1)

2803 (13.5)

 Antidepressante

1903 (13.8)

628 (14.9)

282 (16.3)

198 (18.6)

3011 (14.5)

 Antihypertensivef

2011 (14.6)

649 (15.4)

284 (16.4)

180 (16.9)

3124 (15.1)

 Onabotulinum toxin A

322 (2.3)

94 (2.2)

45 (2.6)

29 (2.7)

490 (2.4)

Survey respondents eligible for migraine preventive medicationa

N/A

4–7 HD/m

(n = 1458)

8–14 HD/m

(n = 792)

 ≥ 15 HD/m

(n = 499)

Total

(N = 2749)

Currentlyb using preventives,c n (%)

 1 preventive

 

173 (11.9)

97 (12.2)

79 (15.8)

349 (12.7)

 2 preventives

 

73 (5.0)

50 (6.3)

41 (8.2)

164 (6.0)

  ≥ 3 preventives

 

104 (7.1)

59 (7.4)

41 (8.2)

204 (7.4)

Currentb preventive medication category,c n (%) – not mutually exclusive

 Antiseizured

 

170 (11.7)

99 (12.5)

72 (14.4)

341 (12.4)

 Antidepressante

 

201 (13.8)

115 (14.5)

99 (19.8)

415 (15.1)

 Antihypertensivef

 

202 (13.9)

121 (15.3)

80 (16.0)

403 (14.7)

 Onabotulinum toxin A

 

37 (2.5)

18 (2.3)

12 (2.4)

67 (2.4)

  1. CGRP-mAbs calcitonin gene-related peptide-monoclonal antibodies, HD/m headache days per month, MIDAS Migraine Disability Assessment
  2. aPatients with ≥ 4 HD/m on average over the last 90 days and ≥ 11 (MIDAS). Users of CGRP-mAbs are excluded
  3. bCurrent defined as taken or used in the last three months for preventive medications
  4. cExcluding CGRP-mAbs
  5. dAntiseizure medications included valproic acid/valproate, gabapentin, pregabalin, topiramate, zonisamide, levetiracetam, clonazepam, lamotrigine, carbamazepine, oxcarbazepine and ‘other antiseizure medication’. Not all medications are licensed in both Germany and Spain
  6. eAntidepressant medications included amitriptyline, desvenlafaxine, doxepin, escitalopram, fluoxetine, imipramine, nortriptyline, paroxetine, sertraline, venlafaxine, clomipramine, trazodone, mianserin, fluvoxamine, sulpiride, mirtazapine, citalopram, opipramol and ‘other antidepressant medication’. Not all medications are licensed in both Germany and Spain
  7. fAntihypertensive medications included atenolol, candesartan, lisinopril, metoprolol, nifedipine, propranolol, verapamil, diltiazem, nicardipine, captopril, enalapril, telmisartan and ‘other blood pressure or heart medication’. Not all medications are licensed in both Germany and Spain