Fig. 1

Reporter gene assays showed that allelic differences at VAMP2_rs1150 (A) and SNAP25_rs2327264 (B), but not at STX1A_rs6951030 (C), influenced luciferase reporter activity. Firefly luciferase activity was normalised to renilla luciferase activity and is shown as a fold change to that of pGL3-promotor or pGL3-basic (n ≥ 4 for each group) for HEK293T and SH-SY5Y cells. Data is presented as the mean ± SD. ns, not significant, * p < 0.05, ** p < 0.01, unpaired student´s t-test