| Placebo + saline + saline n = 5 | Placebo + PACAP38 + VIP n = 10 | Lu AG09222 + PACAP38 + VIP n = 10 |
---|---|---|---|
Period 1a | |||
 Feeling hot | 2 (40.0) | 0 | 0 |
 Headache | 1 (20.0) | 0 | 0 |
Period 2b | |||
 Headache | 4 (80.0) | 9 (90.0) | 4 (40.0) |
 Feeling hot | 0 | 10 (100) | 3 (30.0) |
 Flushing | 0 | 10 (100) | 1 (10.0) |
 Palpitations | 0 | 10 (100) | 0 |
 Fatigue | 2 (40.0) | 2 (20.0) | 2 (20.0) |
 Musculoskeletal stiffness | 0 | 3 (30.0) | 1 (10.0) |
 Disturbance in attention | 1 (20.0) | 0 | 2 (20.0) |
 Nasal congestion | 1 (20.0) | 2 (20.0) | 0 |
 Photosensitivity reaction | 1 (20.0) | 2 (20.0) | 0 |
 Vomiting | 0 | 2 (20.0) | 0 |
Period 3c | |||
 Headache | 2 (40.0) | 7 (70.0) | 4 (40.0) |
 Feeling hot | 0 | 10 (100) | 3 (30.0) |
 Flushing | 0 | 9 (90.0) | 4 (40.0) |
 Palpitations | 0 | 6 (60.0) | 0 |
 Fatigue | 0 | 1 (10.0) | 2 (20.0) |
 Musculoskeletal stiffness | 0 | 0 | 1 (10.0) |
 Disturbance in attention | 0 | 1 (10.0) | 1 (10.0) |
 Photosensitivity reaction | 0 | 1 (10.0) | 0 |