Fig. 3From: Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine painEffect of dual MAGL-FAAH inhibitor AKU-005 on rat meningeal fibres. A Example traces of control basal and AKU-005 (100Â nM) induced activity in rat meningeal fibres. B Statistics show lightly increased general excitability in the presence of AKU-005 as evidenced by an increasing number of APs for the 10-min application window in the presence of AKU-005 (AKU) (Nâ=â19, Wilcoxon test) compared to the control condition (Cntr) (Nâ=â19, Wilcoxon test, **â=â0.002)Back to article page