Fig. 7

Representative images and quantitative analysis of the synaptic ultrastructure in the TNC. A and a show the sham group, B and b show the NTG + vehicle group, C and c show the NTG + OT group, D and d show the NTG + OT + L368,899 group. a-d Magnification of the rectangle frame from each group was used to quantify parameters of the synaptic interface in the four groups. The width of the synaptic cleft (E) was decreased, and the thickness of PSD (F) and the synaptic interface curvature (G) were significantly increased in the NTG + vehicle group compared to the sham group. In the NTG + OT group, these abnormal alterations were alleviated. The morphological parameters in the NTG + OT + L368,899 group were similar to those in the NTG + vehicle group. One-way ANOVA with Dunnett’s post hoc test, n = 4/group; **p < 0.01, ***p < 0.001 vs. the sham group; ##p < 0.01, ###p < 0.001 vs. the NTG + vehicle group; &&p < 0.01, &&&p < 0.001 vs. the NTG + OT group; scale bars: 200 nm; PSD, postsynaptic density; SC, synaptic cleft; SV, synaptic vesicle