Table 3 Statistically significant brain metabolic activity (FDG-PET) differences adjusted by brain structure between healthy controls and migraine subgroups (CM and EM)

Frontal Areas

 Lateral Orbitofrontal

1.605 (0.029)

1.552 (0.036)

1.503 (0.036)

0.296

0.038

0.366

1.598 (0.033)

1.527 (0.040)

1.492 (0.041)

0.201

0.057

0.562

 Medial Orbitofrontal

1.564 (0.034)

1.522 (0.043)

1.413 (0.047)

0.453

0.018

0.132

1.590 (0.033)

1.493 (0.038)

1.469 (0.041)

0.067

0.033

0.686

 Paracentral

1.443 (0.033)

1.438 (0.040)

1.309 (0.042)

0.919

0.019

0.042

1.473 (0.034)

1.438 (0.038)

1.345 (0.041)

0.503

0.030

0.116

 Pars Triangularis

1.724 (0.033)

1.689 (0.040)

1.626 (0.043)

0.506

0.085

0.313

1.749 (0.036)

1.644 (0.041)

1.625 (0.044)

0.074

0.043

0.763

 Precentral

1.559 (0.033)

1.538 (0.040)

1.462 (0.043)

0.703

0.095

0.217

1.560 (0.030)

1.550 (0.035)

1.446 (0.037)

0.821

0.029

0.070

 Superior Frontal

1.623 (0.037)

1.591 (0.043)

1.490 (0.050)

0.572

0.050

0.187

1.607 (0.034)

1.591 (0.040)

1.504 (0.046)

0.766

0.090

0.201

 Frontal Pole

1.702 (0.040)

1.645 (0.049)

1.602 (0.051)

0.385

0.135

0.551

1.778 (0.042)

1.696 (0.047)

1.632 (0.050)

0.220

0.039

0.354

Temporal areas

 Banks Superior Temporal Sulcus

1.548 (0.034)

1.470 (0.040)

1.444 (0.044)

0.152

0.083

0.673

1.584 (0.032)

1.507 (0.035)

1.459 (0.038)

0.127

0.026

0.372

 Inferior Temporal

1.449 (0.026)

1.392 (0.031)

1.354 (0.034)

0.183

0.039

0.426

1.447 (0.023)

1.382 (0.026)

1.362 (0.029)

0.076

0.035

0.631

 Temporal Pole

1.137 (0.021)

1.045 (0.024)

1.038 (0.026)

0.011

0.008

0.840

1.098 (0.021)

0.994 (0.025)

1.005 (0.025)

0.007

0.031

0.357

 Insula

1.373 (0.027)

1.311 (0.032)

1.281 (0.035)

0.162

0.050

0.541

1.388 (0.028)

1.309 (0.032)

1.287 (0.033)

0.080

0.031

0.649

Occipital Areas

 Lateral Occipital

1.550 (0.036)

1.536 (0.042)

1.436 (0.045)

0.815

0.069

0.122

1.630 (0.044)

1.582 (0.048)

1.476 (0.051)

0.489

0.036

0.143