Cortical metabolic and structural differences in patients with chronic migraine. An exploratory 18FDG-PET and MRI study

Table 2 Migraine characteristics

	EM N = 8	CM N = 7	P value
Headache frequency^b, mean (SD), days/month	8.8 (1.8)	24.7 (6.3)	< 0.0001
Disease duration^b, mean (SD), years	28.4 (13.2)	20.0 (19.5)	0.343
Chronification, median (IQR), years	--	4.0 (11.0)	--
Aura^a, n (%)	3 (37.5)	4 (57.1)	0.619
Unilateral Pain^a, n (%)	5 (62.5)	7 (100.0)	0.200
Analgesic Use^c, median (IQR), days/month	0.5 (8.8)	5.0 (8.0)	0.613
MIDAS^c, median (IQR)	9.5 (29.0)	32.0 (89.0)	0.029
HIT-6^b, mean (SD)	60.5 (3.9)	61.3 (4.9)	0.735
MSQ^b, mean (SD) Role Function preventive Role function restrictive Emotional function	53.1 (23.8) 47.9 (17.1) 51.4 (27.2)	51.8 (15.8) 50.0 (13.3) 59.5 (16.3)	0.800 0.901 0.503

Bold font in the P values column indicates statistically significant
^aSignificance assessed with Fisher’s exact test
^bSignificance assessed with independent t-test
^cSignificance assessed with Mann-Whitney U test
HC healthy controls; EM episodic Migraine; CM chronic migraine; SD standard deviation; IQR interquartile range; y years; d/mo days per month; MIDAS migraine disability assessment; HIT6 headache impact test 6; MSQ migraine-specific quality-of-life

ISSN: 1129-2377