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Table 3 Spontaneous and evoked firing rates of VPM thalamic neurons in response to optic stimulation of vlPAG neurons

From: Activation of CamKIIα expressing neurons on ventrolateral periaqueductal gray improves behavioral hypersensitivity and thalamic discharge in a trigeminal neuralgia rat model

 

Tonic firing (spikes/s)

Burst firing (bursts/s)

Spontaneous

Evoked

Spontaneous

Evoked

TN/ChR2

 pre

6.13 ± 1.11

25.21 ± 2.94

0.173 ± 0.049

0.348 ± 0.056

 laser

2.26 ± 1.01***

13.26 ± 2.32**

0.056 ± 0.083**

0.188 ± 0.030**

 post

5.52 ± 0.949

22.26 ± 4.45

0.162 ± 0.056

0.360 ± 0.071

TN/EYFP

 pre

5.67 ± 0.465

23.54 ± 4.65

0.22 ± 0.055

0.488 ± 0.067

 laser

1.90 ± 0.316****

21.46 ± 3.20****

0.19 ± 0.088**

0.463 ± 0.100***

 post

6.098 ± 0.296

23.35 ± 4.05

0.208 ± 0.031

0.535 ± 0.057

  1. Note: TN trigeminal neuralgia, ChR2 channelrhodopsin, EYFP enhanced yellow fluorescent protein, pre pre-stimulation, post post-stimulation, TN/ChR2 TN group receiving optogenetic virus, TN/EYFP TN group receiving null virus, spikes/s spikes per second, bursts/s bursts per second; n = 10 per group; All values are represented as mean ± SD
  2. Significance at **p < 0.01, ***p < 0.001, ****p < 0.0001, compared to pre and post conditions with laser condition (Two-way ANOVA)
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The Journal of Headache and Pain

ISSN: 1129-2377

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