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Fig. 9 | The Journal of Headache and Pain

Fig. 9

From: Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice

Fig. 9

Western blotting analysis showed the expression changes of Myd88 in the bilateral TNC in mice. a The expression of MyD88 was increased by dIoN-CCI surgery compared with the sham group, and BoNT/A injection decreased this upregulation. b The expression of MyD88 did not change in the contralateral TNC by dIoN-CCI surgery compared with the sham group. c-d The expression of MyD88 in the ipsilateral and contralateral TNC was significantly reduced in Tlr2−/− mice compared with wild-type mice following dIoN-CCI surgery. Data was expressed as Mean ± SEM. (n = 4 each group, * P < 0.05 compared with the sham group. # P < 0.05 compared with the TN group, unpaired Student’s t-test) TNC, Trigeminal nucleus caudalis; dIoN-CCI, Chronic constriction injury of distal infraorbital nerve; BoNT/A, Botulinum toxin A

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The Journal of Headache and Pain

ISSN: 1129-2377

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