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Fig. 8 | The Journal of Headache and Pain

Fig. 8

From: Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice

Fig. 8

Double immunostaining of TLR2 and IBA-1 in the ipsilateral TNC induced by dIoN-CCI surgery in mice. a Double immunostaining of TLR2 and IBA-1 in the ipsilateral TNC induced in sham animals. b Double immunostaining of TLR2 and IBA-1 in the ipsilateral TNC in dIoN-CCI animals. c On the day 5 following BoNT/A treatment (on day 19 following dIoN-CCI surgery), double immunostaining of TLR2 and IBA-1 in the ipsilateral TNC in dIoN-CCI + BoNT/A animals. Scale bar = 50 μm, and the scale bar in the enlarged graph is 20 μm. TNC, Trigeminal nucleus caudalis; dIoN-CCI, chronic constriction injury of distal infraorbital nerve; BoNT/A, botulinum toxin A

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The Journal of Headache and Pain

ISSN: 1129-2377

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