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Fig. 7 | The Journal of Headache and Pain

Fig. 7

From: Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice

Fig. 7

Immunostaining analysis showed the protein expression of IBA-1 in the TNC site (the area circled by the white solid circle). a Upregulation of IBA-1 expression in the ipsilateral TNC induced by dIoN-CCI surgery in mice. b Quantitative analysis of IBA-1 immunofluorescence intensity in the ipsilateral and contralateral TNC site in the dIoN-CCI group, as fold of contralateral side to surgery. c Expression of IBA-1 in the ipsilateral TNC in the sham mice. d Upregulation of IBA-1 expression in the ipsilateral TNC in the dIoN-CCI surgery mice. e Quantitative analysis of IBA-1 immunofluorescence intensity in the ipsilateral TNC between sham and dIoN-CCI group. Data was expressed as Mean ± SEM. (n = 3 each group, scale bar = 100 μm, * P < 0.05 compared with the control, unpaired Student’s t-test) TNC, trigeminal nucleus caudalis; dIoN-CCI, chronic constriction injury of distal infraorbital nerve

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The Journal of Headache and Pain

ISSN: 1129-2377

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