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Fig. 6 | The Journal of Headache and Pain

Fig. 6

From: Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice

Fig. 6

The expression of glia activation markers and proinflammatory factors in bilateral TNC site using RT-qPCR. a On the ipsilateral TNC of dIoN-CCI surgery, the mRNA expression of F4/80, CD11b and c-FOS were significantly increased by dIoN-CCI surgery, and BoNT/A treatment significantly decreased their up-regulation. b On the contralateral TNC of dIoN-CCI surgery, only the mRNA expression of c-FOS was increased by dIoN-CCI surgery, and BoNT/A treatment significantly decreased the up-regulation of c-FOS. c On the ipsilateral TNC of dIoN-CCI surgery, the mRNA expression of pro-inflammatory factors IL-1β, TNF-α and IL-6 were significantly elevated by dIoN-CCI surgery, and BoNT/A treatment significantly decreased their up-regulation. d There was no statistically significant difference in the expression of proinflammatory factors on the contralateral TNC of dIoN-CCI surgery. Data was expressed as Mean ± SEM. (n = 4 each group, * P < 0.05, ** P < 0.01, *** P < 0.001 compared with the sham group. ## P < 0.01, ### P < 0.001 compared with the dIoN-CCI group, unpaired Student’s t-test). TNC, Trigeminal nucleus caudalis; dIoN-CCI, Chronic constriction injury of distal infraorbital nerve; BoNT/A, Botulinum toxin A

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The Journal of Headache and Pain

ISSN: 1129-2377

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